Microreaction technology is the logically consistent application of microsystem techniques in chemical reaction and process engineering. Miniaturization in this field is the strategy of success and requires the development of small, inexpensive, independent and versatile chemical reaction units. Microreaction technology is at present regarded as one of the fastest evolving and most promising disciplines in chemical engineering, combinatorial synthesis and analysis, pharmaceutical drug development and molecular biotechnology. A broad range of microstructurable materials is a prerequisite for…mehr
Microreaction technology is the logically consistent application of microsystem techniques in chemical reaction and process engineering. Miniaturization in this field is the strategy of success and requires the development of small, inexpensive, independent and versatile chemical reaction units. Microreaction technology is at present regarded as one of the fastest evolving and most promising disciplines in chemical engineering, combinatorial synthesis and analysis, pharmaceutical drug development and molecular biotechnology. A broad range of microstructurable materials is a prerequisite for microreaction technology and the development of microreactors goes hand in hand with the availability of a number of modem, versatile microfabrication technologies. Today, it is possible to manufacture tbree dimensional microstructures, almost without any restrictions with regard to design and choice of suitable materials, for various chemical applications -just in time to support the development of functional units for microreactors, e. g. micromixers, micro heat exchangers, micro extractors, units for phase transfer, reaction cham bers, intelligent fluidic control elements and microanalysis systems. The advantages of microreactors, e. g. the use of novel process routes, the re duction of reaction byproducts, the improvement of 'time to market', the high flexibility for all applications requiring modular solutions, have had a strong im pact on concepts of sustainable development. Many of the leading companies and research institutes in the world have recognized the tremendous possibilities of microreactor concepts and of their economic potential, and have thus initiated worldwide research and development activities.
Prof. Wolfgang Ehrfeld ist Leiter des Instituts für Mikrotechnik in Mainz, das führend in der Entwicklung und Herstellung von mikrotechnischen Baustein n für die Industrie ist.
Inhaltsangabe
1 Reaction Engineering Aspects of Microreaction Systems.- Reaction Engineering for Microreactor Systems.- Observations on Hypothetical Miniaturised, Disposable Chemical Plant.- Monolithic Microreactors Possessing Regular Mesopore Systems for the Successful Performance of Heterogeneously Catalysed Reactions.- Scouting Study about the Use of Microreactors for Gas Supply in a PEM Fuel Cell System for Traction.- Solute Transfer by Liquid/Liquid Exchange without Mixing in Micro-Contactor Devices.- Reactions in Microreactors in Electric Fields.- High-Temperature Micro Catalysis: a New Design for Comperative Reaction Studies in Technical and Model Systems.- Micro-Structure Electrodes as Electronic Interface between Solid and Gas Phase: Electrically Steerable Catalysts for Chemical Reactions in the Gas Phase.- 2 Design and Production of Microreactor Systems.- Fabrication of Components and Systems for Chemical and Biological Microreactors.- Technologies and Microstructures for (Bio)chemical Microsystems.- Functionalized Biomolecular Membranes for Microreactors.- Nano Titer Plates: Micro Compartment Arrays for Biotechnological Applications.- An Automated Method to Create a One Dimensional Array of Chemically Synthesized Oligonucleotides.- Development of a Microreactor for Chemical Production.- Laser Processes for Flexible Manufacturing of Fluidic Micro Reactors.- The Use of Microcapillaries and Catalytic Contact Printing for the Preparation of Microstructured Magnetic Surfaces and for the Ordered Deposition of Proteins on Surfaces.- Fabrication and Interconnection of Ceramic Microreaction Systems for High Temperature Applications.- Fabrication of Microreactor Components by Electro Discharge Machining.- Silicon Microreactors made by Reactive Ion Etching.- Porous Silicon as the Carrier Martix in a Micro Enzyme Reactor to Achieve a Highly Efficient and Long-Term Stable Glucose Sensor.- 3 Microreactors in Combinatorial Chemistry.- MCR X. Important Aspects for Automating Preparative Chemistry.- MCR XII. Efficient Development of New Drugs by Online-Optimization of Molecular Libraries.- MCR XI. Microreactors as Processors for Chemical Computers.- 4 Application of Microreactors in Drug Development and Biotechnology.- Microfabricated Devices for Performing Chemical and Biochemical Analysis.- A New Design of a Wafer Based Micro Reaction System.- A Silicon Microreactor for Immunological Applications.- A Microflow Reactor for Two Dimensional Investigations of In Vitro Amplification Systems.- Flourescence Correlation Spectroscopy (FCS), the Detection Method for Sub-Microliter Miniaturized Biological Assays.- The Physiocontrol-Microsystem (PCM): Analysis of Cellular Behaviour for Biomedical Research.- Development of a Pharmacological Test System in a Miniaturized Hollow Fiber Bioreactor.- A Microreactor with On-line Mass Spectrometry for the Investigation of Biological Kinetics.- Microarray Based Ligand Binding System.- 5 Application of Microreactors in Chemical Analysis and Diagnosis.- Advantages Afforded by Miniaturization and Integration of DNA Analysis Instrumentation.- Nanoscaled Impedimetric Sensors for Multiparameter Testing of Biochemical Samples.- Temperature Controlled Chip Reactor for Rapid PCR.- Incremental Parallel Microtitrtation: A Novel Approach Towards Test Strip Devices of Extreme Accuracy.- Concept of Miniaturized and fast GC and HPLC Analytical Systems Integrated in Microreactors.- Possibilities for Thermophysical Reaction Monitoring in Microreactors.- Heating and Calorimetry in Single Droplets and Micro Fluid Reactors.- Microreactions onthe Surface of an Oligonucleotide Bearing Chip.- Coulometric Nanotitrators with Potentiometrie Endpoint Detection.- Miniaturization as a Demand of High-Throughput-Synthesis and -Analysis of Biomolecules.
1 Reaction Engineering Aspects of Microreaction Systems.- Reaction Engineering for Microreactor Systems.- Observations on Hypothetical Miniaturised, Disposable Chemical Plant.- Monolithic Microreactors Possessing Regular Mesopore Systems for the Successful Performance of Heterogeneously Catalysed Reactions.- Scouting Study about the Use of Microreactors for Gas Supply in a PEM Fuel Cell System for Traction.- Solute Transfer by Liquid/Liquid Exchange without Mixing in Micro-Contactor Devices.- Reactions in Microreactors in Electric Fields.- High-Temperature Micro Catalysis: a New Design for Comperative Reaction Studies in Technical and Model Systems.- Micro-Structure Electrodes as Electronic Interface between Solid and Gas Phase: Electrically Steerable Catalysts for Chemical Reactions in the Gas Phase.- 2 Design and Production of Microreactor Systems.- Fabrication of Components and Systems for Chemical and Biological Microreactors.- Technologies and Microstructures for (Bio)chemical Microsystems.- Functionalized Biomolecular Membranes for Microreactors.- Nano Titer Plates: Micro Compartment Arrays for Biotechnological Applications.- An Automated Method to Create a One Dimensional Array of Chemically Synthesized Oligonucleotides.- Development of a Microreactor for Chemical Production.- Laser Processes for Flexible Manufacturing of Fluidic Micro Reactors.- The Use of Microcapillaries and Catalytic Contact Printing for the Preparation of Microstructured Magnetic Surfaces and for the Ordered Deposition of Proteins on Surfaces.- Fabrication and Interconnection of Ceramic Microreaction Systems for High Temperature Applications.- Fabrication of Microreactor Components by Electro Discharge Machining.- Silicon Microreactors made by Reactive Ion Etching.- Porous Silicon as the Carrier Martix in a Micro Enzyme Reactor to Achieve a Highly Efficient and Long-Term Stable Glucose Sensor.- 3 Microreactors in Combinatorial Chemistry.- MCR X. Important Aspects for Automating Preparative Chemistry.- MCR XII. Efficient Development of New Drugs by Online-Optimization of Molecular Libraries.- MCR XI. Microreactors as Processors for Chemical Computers.- 4 Application of Microreactors in Drug Development and Biotechnology.- Microfabricated Devices for Performing Chemical and Biochemical Analysis.- A New Design of a Wafer Based Micro Reaction System.- A Silicon Microreactor for Immunological Applications.- A Microflow Reactor for Two Dimensional Investigations of In Vitro Amplification Systems.- Flourescence Correlation Spectroscopy (FCS), the Detection Method for Sub-Microliter Miniaturized Biological Assays.- The Physiocontrol-Microsystem (PCM): Analysis of Cellular Behaviour for Biomedical Research.- Development of a Pharmacological Test System in a Miniaturized Hollow Fiber Bioreactor.- A Microreactor with On-line Mass Spectrometry for the Investigation of Biological Kinetics.- Microarray Based Ligand Binding System.- 5 Application of Microreactors in Chemical Analysis and Diagnosis.- Advantages Afforded by Miniaturization and Integration of DNA Analysis Instrumentation.- Nanoscaled Impedimetric Sensors for Multiparameter Testing of Biochemical Samples.- Temperature Controlled Chip Reactor for Rapid PCR.- Incremental Parallel Microtitrtation: A Novel Approach Towards Test Strip Devices of Extreme Accuracy.- Concept of Miniaturized and fast GC and HPLC Analytical Systems Integrated in Microreactors.- Possibilities for Thermophysical Reaction Monitoring in Microreactors.- Heating and Calorimetry in Single Droplets and Micro Fluid Reactors.- Microreactions onthe Surface of an Oligonucleotide Bearing Chip.- Coulometric Nanotitrators with Potentiometrie Endpoint Detection.- Miniaturization as a Demand of High-Throughput-Synthesis and -Analysis of Biomolecules.
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