microRNA: Medical Evidence

From Molecular Biology to Clinical Practice
Herausgegeben:Santulli, Gaetano

• Gebundenes Buch

Produktbeschreibung

This volume provides a wide-ranging outline of the role of microRNA in clinical practice, including the most updated notions and recently discovered disease mechanisms in several conditions, including aging, cardiovascular and neurodegenerative disorders, allergy, skin disease, hematopoiesis, diabetes, metabolism, and transplantation. These topics are discussed by worldwide renowned experts in the field, working in prestigious universities. The present book represents the third volume - focused on the clinical importance of microRNAs - of a trilogy exploring the functional roles of microRNAs from biology to the clinical scenario. The first volume provides an overview of the role of microRNAs in molecular and cellular biology and basic science whereas the second volume addresses in detail the relationship between microRNA and cancer. The book includes numerous color photographs, schemes, diagrams, and tables that support and complement the text.

In summary, the book provides a current, state-of-the-art overview of the literature of this expanding and fascinating field. The three volumes will be of value to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA from biology to clinical practice.

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This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today's initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling.

microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Scienceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the
molecular level to clinical
practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

Produktdetails

• Advances in Experimental Medicine and Biology 888
• Verlag: Springer / Springer International Publishing / Springer, Berlin
• Artikelnr. des Verlages: 978-3-319-22670-5
• 1st ed. 2015
• Seitenzahl: 448
• Erscheinungstermin: 21. Dezember 2015
• Englisch
• Abmessung: 241mm x 160mm x 28mm
• Gewicht: 859g
• ISBN-13: 9783319226705
• ISBN-10: 3319226703
• Artikelnr.: 43181382

Autorenporträt

Dr. Gaetano Santulli received his MD and PhD at the University of Naples "Federico II". A physician scientist, Dr. Santulli completed his postdoctoral training at Columbia University Medical Center in New York City, supported by an AHA fellowship and a Scientist Development Grant. Cardiologist, he authored more than 100 publications, including peer-reviewed articles in high impact journals, book chapters, and medical books. He is currently a faculty member of Columbia University. He lives in Manhattan. Dr. Santulli's expertise comprises both clinical and basic research topics, including hypertension, diabetes, angiogenesis, heart failure, arrhythmias, vascular disorders, and skeletal muscle disease. He is a member of several international academic societies, including New York Academy of Sciences, American Heart Association (AHA), American Diabetes Association, European Society of Cardiology, Endocrine Society, American Association for the Advancement of Science, European Association of Heart Failure, European Association of Echocardiography, Acute Cardiovascular Care Association, European Association of Percutaneous Cardiovascular Interventions. He serves on the Editorial Boards of numerous medical Journals.

Inhaltsangabe

.- 1) microRNA and personalized medicine .- 2) microRNA and chronic pain .- 3) microRNA and multiple sclerosis .- 4) microRNA and epilepsy .- 5) microRNA and autism .- 6) microRNAs and fragile X syndrome .- 7) microRNAs and neurodegenerative disorders .- 8) microRNA and metabolism: focus on mitochondria .- 9) microRNA in cerebrovascular diseases .- 10) microRNA and cardiac regeneration .- 11) microRNA and arterial .- 12) microRNA and pulmonary hypertension .

- 13) microRNA and diabetic kidney disease .- 14) MicroRNA and kidney transplantation .- 15) microRNA and wound healing .- 16) microRNA in dermatology .- 17) microRNA and allergy .- 18) Endometriosis .- 19) microRNA role in human .- 20) microRNA and hepatitis B .- 21) BIO microRNA and aging.- 22) microRNA and doping .- 23) microRNA profiling.