MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to…mehr
MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Krishnarao Appasani is the Founder and Chief Executive Officer of Gene Expression Systems, a gene discovery company, focusing on functional genomics in cancer research. He is the Editor of RNA Interference: From Basic Science to Drug Development (2005).
Inhaltsangabe
Foreword Foreword Introduction Part I. Discovery of MicroRNAs in Various Organisms: 1. The microRNAs of C. elegans 2. Non-coding RNAs - development of man-made vector-based intronic microRNAs 3. Seeing is believing: strategies for studying microRNA expression 4. MicroRNAs in limb development 5. Identification of miRNAs in plant oryza sativa Part II. MicroRNA Functions and RNAi-Mediated Pathways: 6. Inhibition of translation initiation by a microRNA 7. In situ analysis of microRNA expression during vertebrate development 8. MicroRNA function in the nervous system 9. Micro RNA expression that controls the amount of branched chain ¿-ketoacid dehydrogenase in mitochondria of human cells 10. MicroRNAs and the regulation of leaf shape Part III. Computational Biology of MicroRNAs: 11. MiRBase: a database of microRNA sequences, targets and nomenclature 12. Computational prediction of microRNA targets in vertebrates, fruitflies and nematodes 13. Computational approaches to elucidate miRNA biology 14. The RNA hybrid approach to microRNA target prediction 15. Machine learning predicts microRNA target sites 16. Models of microRNA-target coordination Part IV. Detection and Quantitation of MicroRNAs: 17. Detection and analysis of microRNAs using LNA (locked nucleic acid)-modified probes 18. Detection and quantitation of microRNAs using the RNA Invader® assay 19. A single molecule method to quantify miRNA gene expression 20. Real-time quantification of MicroRNAs by TaqMan® assays 21. Real-time quantification of miRNAs and mRNAs employing universal reverse transcription Part V. MicroRNAs in Disease Biology: 22. Dysregulation of microRNAs in human malignancy 23. High throughput microRNAs profiling in cancers 24. Roles of microRNAs in cancer and development 25. MiR-122 in mammalian liver 26. MiRNAs in glioblastoma 27. Role of microRNA pathway in Fragile X mental retardation 28. Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia 29. MiRNAs in TPA-induced differentiation of HL-60 cells 30. MiRNAs in skeletal muscle differentiation 31. Identification and potential function of viral microRNAs 32. Lost in translation: regulation of HIV-1 by microRNAs and a key enzyme of RNA-directed RNA polymerase Part VI. MicroRNAs in Stem Cell Development: 33. MicroRNAs in the stem cells of the mouse Blastocyst 34. The role of miRNA in hematopoiesis 35. MicroRNAs in embryonic stem cell differentiation and prediction of their targets 36. Generation of single cell microRNA expression profile.
Foreword Foreword Introduction Part I. Discovery of MicroRNAs in Various Organisms: 1. The microRNAs of C. elegans 2. Non-coding RNAs - development of man-made vector-based intronic microRNAs 3. Seeing is believing: strategies for studying microRNA expression 4. MicroRNAs in limb development 5. Identification of miRNAs in plant oryza sativa Part II. MicroRNA Functions and RNAi-Mediated Pathways: 6. Inhibition of translation initiation by a microRNA 7. In situ analysis of microRNA expression during vertebrate development 8. MicroRNA function in the nervous system 9. Micro RNA expression that controls the amount of branched chain ¿-ketoacid dehydrogenase in mitochondria of human cells 10. MicroRNAs and the regulation of leaf shape Part III. Computational Biology of MicroRNAs: 11. MiRBase: a database of microRNA sequences, targets and nomenclature 12. Computational prediction of microRNA targets in vertebrates, fruitflies and nematodes 13. Computational approaches to elucidate miRNA biology 14. The RNA hybrid approach to microRNA target prediction 15. Machine learning predicts microRNA target sites 16. Models of microRNA-target coordination Part IV. Detection and Quantitation of MicroRNAs: 17. Detection and analysis of microRNAs using LNA (locked nucleic acid)-modified probes 18. Detection and quantitation of microRNAs using the RNA Invader® assay 19. A single molecule method to quantify miRNA gene expression 20. Real-time quantification of MicroRNAs by TaqMan® assays 21. Real-time quantification of miRNAs and mRNAs employing universal reverse transcription Part V. MicroRNAs in Disease Biology: 22. Dysregulation of microRNAs in human malignancy 23. High throughput microRNAs profiling in cancers 24. Roles of microRNAs in cancer and development 25. MiR-122 in mammalian liver 26. MiRNAs in glioblastoma 27. Role of microRNA pathway in Fragile X mental retardation 28. Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia 29. MiRNAs in TPA-induced differentiation of HL-60 cells 30. MiRNAs in skeletal muscle differentiation 31. Identification and potential function of viral microRNAs 32. Lost in translation: regulation of HIV-1 by microRNAs and a key enzyme of RNA-directed RNA polymerase Part VI. MicroRNAs in Stem Cell Development: 33. MicroRNAs in the stem cells of the mouse Blastocyst 34. The role of miRNA in hematopoiesis 35. MicroRNAs in embryonic stem cell differentiation and prediction of their targets 36. Generation of single cell microRNA expression profile.
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