This book provides a comprehensive presentation of all types of HTSC and includes a broad overview on HTSC computer simulations and modeling. Especial attention is devoted to the Bi-Sr-Ca-Cu-O and Y-Ba-Cu-O families that today are the most perspective for applications. The book includes a great number of illustrations and references. The monograph is addressed to students, post-graduate students and specialists, taking part in the development, preparation and researching of new materials. The main features of high-temperature superconductors (HTSC) that define their properties are intrinsic brittleness of oxide cuprates, the layered anisotropic structure and the supershort coherence length. Taking into account these features, this treatise presents research into HTSC microstructure and properties, and also explores the possibilities of optimization of the preparation techniques and superconducting compositions. The "composition-technique-experiment-theory-model," employed here, assumes considerable HTSC defectiveness and structure heterogeneity and helps to draw a comprehensive picture of modern representations of the microstructure, strength and the related structure-sensitive properties of the materials considered. Special attention is devoted to the Bi-Sr-Ca-Cu-O and Y-Ba-Cu-O families, which currently offer the most promising applications. Including a great number of illustrations and references, this monograph addresses students, post-graduate students and specialists, taking part in the development, preparation and research of new materials. This English-language edition incorporates key developments reported since the original Russian-language edition (2004).