The decision, in 1975, to write alone a monograph on micro tubules was not without risks. While I was familiar from its start in Brussels in 1934 with the work on col chicine and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. However, this monograph, which, contrary to other works on microtubules, tried to cover the whole field of research, from the fundamentals of the tubulin molecule and the possible role of these organelles in some aspects of human pathology, to some medical applications of microtubule poisons, has been…mehr
The decision, in 1975, to write alone a monograph on micro tubules was not without risks. While I was familiar from its start in Brussels in 1934 with the work on col chicine and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. However, this monograph, which, contrary to other works on microtubules, tried to cover the whole field of research, from the fundamentals of the tubulin molecule and the possible role of these organelles in some aspects of human pathology, to some medical applications of microtubule poisons, has been accepted as a useful tool for workers in these fields. Since 1976, (date of the last references mentioned in the monograph) until the middle of 1983, papers on microtubule research have literally been pouring in, at the rate of several hundred a year. This may justify a second edition, although the considerable difficulties in keeping the size of the book within the same limits while not forgetting to mention some important work, could not be overlooked. The need for an entirely revised and rewritten edition prompted this new venture and was possible with the help of the considerable amount of reprints kindly sent to me day after day over the years. This work would have been unthinkable if the author had not maintained the same enthusiasm for microtubule research, which has been disclosing new facts every day.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
From the Introduction to the First Edition.- Acknowledgments.- 1 Historical Background.- 1.1 Micro tubules (MT).- 1.2 Colchicine: A Specific MT Poison.- 1.3 Other MT Poisons.- 1.4 Action of Physical Agents.- 1.5 Conclusion.- References.- 2 Structure and Chemistry of Microtubules.- 2.1 Introduction.- 2.2 General Morphology of MT.- 2.3 Structure of MT.- 2.4 Biochemistry of MT and Associated Proteins.- 2.5 Assembly and Disassembly of MT in Vitro.- 2.6 Summary.- References.- 3 General Physiology of Tubulins and Microtubules.- 3.1 Introduction.- 3.2 Tubulin Synthesis and Its Regulation.- 3.3 Assembly of MT in Vivo.- 3.4 Relations of MT with Other Cell Structures and Organelles.- 3.5 Relations with Viruses and Endocellular Parasites.- 3.6 Extracellular MT.- References.- 4 Complex Microtubule Assemblies: Axonemes, Centrioles, Basal Bodies, Cilia, and Flagella.- 4.1 Introduction.- 4.2 Axonemes.- 4.3 Centrioles.- 4.4 Cilia and Flagella. Introduction.- 4.5 Basal Bodies.- 4.6 Regeneration of Cilia and Ciliogenesis.- 4.7 Atypical and Pathological Cilia.- References.- 5 Microtubule Poisons.- 5.1 Introduction.- 5.2 Colchicine and Colchicine Derivatives.- 5.3 The Catharanthus (Vinca) Alkaloids.- 5.4 Podophyllotoxin and Related Molecules.- 5.5 Sulfhydryl Reagents.- 5.6 The Benzimidazole Derivatives.- 5.7 Griseofulvin.- 5.8 Anesthetic Drugs.- 5.9 Other MT Poisons.- 5.10 Taxol: An Agent That Favorizes MT Assembly.- 5.11 Action of Physical Agents and Heavy Water.- References.- 6 Cell Shape.- 6.1 Introduction.- 6.2 Disk-Shaped Blood Cells.- 6.3 Nuclear and Cytoplasmic Shaping in Spermatogenesis.- 6.4 Other Cytoskeletal Functions of MT in Metazoa.- 6.5 Egg Differentiation and Embryonic Growth.- 6.6 Cell Shape in Plants.- 6.7 Cell Shape in Protozoa.- 6.8 MT with Mechanical Functions.- References.- 7 Cell Movement.- 7.1 Introduction.- 7.2 Intracellular Displacements and Motion.- 7.3 The Movement of Pigment Granules.- 7.4 Movements of Cell Membranes and "Capping".- 7.5 Cell Motility and Locomotion.- 7.6 Ciliary Movements.- References.- 8 Secretion.- 8.1 Introduction.- 8.2 Endocrine Secretions.- 8.3 Exocrine Secretions.- 8.4 Leukocytes and Related Cells.- 8.5 Other Cell Activities Related to Secretion.- 8.6 Conclusions.- References.- 9 Neurotubules and Neuroplasmic Transport.- 9.1 Introduction.- 9.2 General Properties of Nerve MT.- 9.3 Relations of MT with Synaptic Vesicles.- 9.4 Microtubules and Nerve Cells Shape.- 9.5 Experimental Changes of Neuronal MT.- 9.6 Neuroplasmic Transport and MT.- 9.7 Role of MT in Axoplasmic Transport.- 9.8 Theories of Neuroplasmic Transport.- 9.9 MT and Sensory Cells.- References.- 10 Microtubules and Mitosis.- 10.1 Introduction.- 10.2 Some Aspects of the Possible Evolution of Mitosis.- 10.3 Some Types of Mitosis.- 10.4 Methods of Study.- 10.5 MT and Mitotic Movements.- 10.6 Other Proteins Associated with Mitotic MT.- 10.7 The Action of MT Poisons on Mitosis.- 10.8 The Action of Physical Factors on Mitosis.- 10.9 Microtubules and the Mechanisms of Mitosis.- 10.10 Conclusions.- References.- 11 MT and MT Poisons in Pathology and Medicine.- 11.1 Introduction.- 11.2 Pathology of MT Structures.- 11.3 Therapeutic Uses of MT Poisons.- 11.4 The Toxicity of the Vinca (Catharanthus) Alkaloids.- 11.5 Toxicity of MT Poisons in Cancer Chemotherapy 433 References.- 12 Post-Script and Outlook.- 12.1 Unity and Diversity.- 12.2 Microtubule-Associated Proteins (MAPs).- 12.3 Assembly and Disassembly.- 12.4 Microtubule Poisons.- 12.5 Non-Microtubular Tubulin.- 12.6 Micro tubules and Movement.- 12.7 Micro tubules and Cell Shape.- 12.8 Microtubules and Evolution.- References.- Addenda Some of the Most Interesting Papers Published in 1983 and Early in 1984.- Recent Books and Reviews on Microtubules and Related Subjects.
From the Introduction to the First Edition.- Acknowledgments.- 1 Historical Background.- 1.1 Micro tubules (MT).- 1.2 Colchicine: A Specific MT Poison.- 1.3 Other MT Poisons.- 1.4 Action of Physical Agents.- 1.5 Conclusion.- References.- 2 Structure and Chemistry of Microtubules.- 2.1 Introduction.- 2.2 General Morphology of MT.- 2.3 Structure of MT.- 2.4 Biochemistry of MT and Associated Proteins.- 2.5 Assembly and Disassembly of MT in Vitro.- 2.6 Summary.- References.- 3 General Physiology of Tubulins and Microtubules.- 3.1 Introduction.- 3.2 Tubulin Synthesis and Its Regulation.- 3.3 Assembly of MT in Vivo.- 3.4 Relations of MT with Other Cell Structures and Organelles.- 3.5 Relations with Viruses and Endocellular Parasites.- 3.6 Extracellular MT.- References.- 4 Complex Microtubule Assemblies: Axonemes, Centrioles, Basal Bodies, Cilia, and Flagella.- 4.1 Introduction.- 4.2 Axonemes.- 4.3 Centrioles.- 4.4 Cilia and Flagella. Introduction.- 4.5 Basal Bodies.- 4.6 Regeneration of Cilia and Ciliogenesis.- 4.7 Atypical and Pathological Cilia.- References.- 5 Microtubule Poisons.- 5.1 Introduction.- 5.2 Colchicine and Colchicine Derivatives.- 5.3 The Catharanthus (Vinca) Alkaloids.- 5.4 Podophyllotoxin and Related Molecules.- 5.5 Sulfhydryl Reagents.- 5.6 The Benzimidazole Derivatives.- 5.7 Griseofulvin.- 5.8 Anesthetic Drugs.- 5.9 Other MT Poisons.- 5.10 Taxol: An Agent That Favorizes MT Assembly.- 5.11 Action of Physical Agents and Heavy Water.- References.- 6 Cell Shape.- 6.1 Introduction.- 6.2 Disk-Shaped Blood Cells.- 6.3 Nuclear and Cytoplasmic Shaping in Spermatogenesis.- 6.4 Other Cytoskeletal Functions of MT in Metazoa.- 6.5 Egg Differentiation and Embryonic Growth.- 6.6 Cell Shape in Plants.- 6.7 Cell Shape in Protozoa.- 6.8 MT with Mechanical Functions.- References.- 7 Cell Movement.- 7.1 Introduction.- 7.2 Intracellular Displacements and Motion.- 7.3 The Movement of Pigment Granules.- 7.4 Movements of Cell Membranes and "Capping".- 7.5 Cell Motility and Locomotion.- 7.6 Ciliary Movements.- References.- 8 Secretion.- 8.1 Introduction.- 8.2 Endocrine Secretions.- 8.3 Exocrine Secretions.- 8.4 Leukocytes and Related Cells.- 8.5 Other Cell Activities Related to Secretion.- 8.6 Conclusions.- References.- 9 Neurotubules and Neuroplasmic Transport.- 9.1 Introduction.- 9.2 General Properties of Nerve MT.- 9.3 Relations of MT with Synaptic Vesicles.- 9.4 Microtubules and Nerve Cells Shape.- 9.5 Experimental Changes of Neuronal MT.- 9.6 Neuroplasmic Transport and MT.- 9.7 Role of MT in Axoplasmic Transport.- 9.8 Theories of Neuroplasmic Transport.- 9.9 MT and Sensory Cells.- References.- 10 Microtubules and Mitosis.- 10.1 Introduction.- 10.2 Some Aspects of the Possible Evolution of Mitosis.- 10.3 Some Types of Mitosis.- 10.4 Methods of Study.- 10.5 MT and Mitotic Movements.- 10.6 Other Proteins Associated with Mitotic MT.- 10.7 The Action of MT Poisons on Mitosis.- 10.8 The Action of Physical Factors on Mitosis.- 10.9 Microtubules and the Mechanisms of Mitosis.- 10.10 Conclusions.- References.- 11 MT and MT Poisons in Pathology and Medicine.- 11.1 Introduction.- 11.2 Pathology of MT Structures.- 11.3 Therapeutic Uses of MT Poisons.- 11.4 The Toxicity of the Vinca (Catharanthus) Alkaloids.- 11.5 Toxicity of MT Poisons in Cancer Chemotherapy 433 References.- 12 Post-Script and Outlook.- 12.1 Unity and Diversity.- 12.2 Microtubule-Associated Proteins (MAPs).- 12.3 Assembly and Disassembly.- 12.4 Microtubule Poisons.- 12.5 Non-Microtubular Tubulin.- 12.6 Micro tubules and Movement.- 12.7 Micro tubules and Cell Shape.- 12.8 Microtubules and Evolution.- References.- Addenda Some of the Most Interesting Papers Published in 1983 and Early in 1984.- Recent Books and Reviews on Microtubules and Related Subjects.
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