Microwave assisted synthesis and antimicrobial evaluation

Microwave assisted synthesis and antimicrobial evaluation

of furanyl thiazole based pyrimidine analogs

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Pyrimidines occupy a unique and distinctive role biologically and medicinally. The analogs of pyrimidine are used as antibacterial1-4, anticonvulsant, antiprotozoal, antiviral, antihypertensive, antihistaminic and antifungal and anti-inflammatory agents. Numerous drugs were developed involving pyrimidine ring. Some drugs have either modified pyrimidine ring (flucytosine, Idoxuridine) or pyrimidine ring in fused form with other heterocycles (methotrexate, prazocin) and in some drugs, pyrimidines are commonly employed as substituent on lead moieties (sulphonamides). Halogenated pyrimidines and a...