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In the present study, we have investigated the microwave assisted synthesis of several (E)-1-(1-Substituted naphthalen-2-yl)-3-(2-substituted quinolin-3-yl)prop-2-en-1-ones by base catalyzed Claisen-Schmidt condensation reaction of 2-Morpholinoquinoline-3-carbaldehyde/ 2- Piperidinoquinoline-3-carbaldehyde/ 2-Pyrrolidinoquinoline-3-carbaldehyde with 1-(1-Hydroxynaphthalen-2-yl) ethanone/ 1-(1-Methoxynaphthalen-2- yl)ethanone. The structures of the newly synthesized compounds were confirmed by elemental analysis, and spectral data such as IR, 1H & 13C NMR and Mass