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This work represents the synthesis of some novel 4 (3H)Quinazolinone analogues and their pharmacological activities. The structural modifications on Quinazolinone nucleus showed a wide range of biological activities like antioxidant, H1antihistaminic activity, anti-inflammatory and anti-tumour agents such as ethyldiamino imidazolines and ethyl diamino quinoline group is built into position 3 of the quinazolinone nucleus.