Mineral trioxide aggregate (MTA) has recently been investigated as a potential alternative restorative material to the presently used materials in endodontics. Several studies have shown that MTA prevents microleakage, is biocompatible, and promotes regeneration of the original tissues when it is placed in contact with dental pulp and peri radicular tissues. MTA materials appear not only to demonstrate acceptable biocompatible behavior but also exhibits acceptable in vivo biologic performance when used for root-end fillings, perforation repairs, pulp-capping and pulpotomy, and apexification treatment.