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Human has done this work previously unconsciously on domestic dogs. Human has created dogs in different sizes artificially without any awareness of mechanism of this action. By the help of this research it is possible to create domestic animals in desired size consciously and open-eyed. Physiological factor of amount controlling of mammal's bulk is the amount of organic phosphates (like DPG) existing in red blood cells of mammals. Organic phosphates make the stickiness between the oxygen molecules and hemoglobin weaker so there is a opposite relationship between the amount of organic phosphate and the stickiness power. The less the amount of organic phosphates, the larger the size of mammals.