MITOCHONDRIAL APOPTOSIS - Chauhan, Shweta Singh;Lahanger, Vijay;Shrivastava, Kush
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In mitochondrial apoptotic pathways basically, the release of the proapoptotic proteins from the intermembrane space triggers apoptosis, in a caspase-dependent (through cytochrome- c, Omi/HtrA2 and SMAC) as well as in a caspase-independent form (through AIF and endonuclease G). Apoptosis acts as a biological link between cancer genetics and cancer therapy. The development of malignant tumors results from deregulated proliferation or an inability of cells to undergo apoptotic cell death. Since apoptotic pathway can be manipulated to produce massive changes in cell death, the genes and proteins…mehr

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Produktbeschreibung
In mitochondrial apoptotic pathways basically, the release of the proapoptotic proteins from the intermembrane space triggers apoptosis, in a caspase-dependent (through cytochrome- c, Omi/HtrA2 and SMAC) as well as in a caspase-independent form (through AIF and endonuclease G). Apoptosis acts as a biological link between cancer genetics and cancer therapy. The development of malignant tumors results from deregulated proliferation or an inability of cells to undergo apoptotic cell death. Since apoptotic pathway can be manipulated to produce massive changes in cell death, the genes and proteins controlling apoptosis are potential drug targets. Although many of the key apoptotic proteins that are activated or inactivated in the apoptotic pathways have been identified, the molecular mechanisms of action or activation of these proteins are not fully understood and are the focus of continued research.
Autorenporträt
Dr. Shweta Singh Chauhan hat ihr Masterstudium in Veterinärbiochemie mit Auszeichnung abgeschlossen. Während ihrer Forschungskarriere hat sie sich ausgiebig mit Apoptose beschäftigt und mehr als 20 internationale Forschungsarbeiten zu diesem Thema veröffentlicht. Das vorliegende Buch ist ihr Versuch, die Komplexität der mitochondrialen Apoptose zu vereinfachen.