Mitomycin Alkaloids: Synthetic Studies - Gubler, Daniel
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Documented herein are efforts towards the first asymmetric total synthesis of the mitomycin family of natural products. Methods have been developed that efficiently construct eight-membered benzazocine ring precursors of the natural products. Additionally, a tetracyclic mitosane compound containing all the core features of the mitomycins except the C9a methyl aminal has been constructed. The above-mentioned synthetic efforts help set the stage for future completion of the asymmetric total synthesis of this family of compounds. The studies mentioned herein shed new light on the reactivity of…mehr

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Produktbeschreibung
Documented herein are efforts towards the first asymmetric total synthesis of the mitomycin family of natural products. Methods have been developed that efficiently construct eight-membered benzazocine ring precursors of the natural products. Additionally, a tetracyclic mitosane compound containing all the core features of the mitomycins except the C9a methyl aminal has been constructed. The above-mentioned synthetic efforts help set the stage for future completion of the asymmetric total synthesis of this family of compounds. The studies mentioned herein shed new light on the reactivity of the mitomycins as well as the remarkable electronic effect of the electron-rich arene ring.
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Autorenporträt
Daniel Gubler received his B.S. degree in biochemistry from Brigham Young University in 2003, his Ph.D. in organic synthesis in 2009 from Colorado State University, and did postdoctoral research at the California Institute of Technology in bioorganic chemistry from 2009-2010. He is currently an assistant professor of chemistry at BYU-Hawaii.