Mitophagy in Health and Disease

Mechanisms, Health Implications, and Therapeutic Opportunities
Herausgeber: Lemasters, John J

• Broschiertes Buch

Produktbeschreibung

Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention. This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.

Produktdetails

• Verlag: Elsevier Health Sciences
• Seitenzahl: 350
• Erscheinungstermin: 1. Oktober 2024
• Englisch
• Abmessung: 235mm x 191mm
• Gewicht: 450g
• ISBN-13: 9780443152603
• ISBN-10: 0443152608
• Artikelnr.: 67523364

Inhaltsangabe

About the editor 1. Overview on mitophagy, mito-dynamics, and
mito-biogenesis 2. PINK1-Parkin mitochondrial quality control pathway in
Parkinson’s disease 3. Ubiquitin-independent mitophagy: mechanisms and
pathophysiological functions 4. Role of AMPK/ULK1 signaling in mitophagy 5.
Mitochondrial proteostasis mechanisms (AAA proteases including Lon,
proteasomes, CLpP) 6. MitoUPR 7. Mitochondria Derived Vesicles: from
Quality Control to Inflammation and Extracellular Vesicles 8. Molecular
Regulation of Mitochondrial Turnover by Exercise: Tissue Adaptation through
Mitochondrial Biogenesis and Mitophagy 9. Role of mitophagy and
mitochondria in aging and cellular senescence 10. Mitophagy in
erythropoiesis 11. The dual role of mitophagy in cancer and its targeting
for effective anticancer therapy 12. Mitophagy in brain and
neurodegenerative disease 13. Anti-aging role of mitophagy 14. Mitophagy in
age-associated disease 15. Mitophagy inducers as potential therapeutic
agents 16. Transcription factor EB (TFEB) in mitochondrial quality control
17. Cardioprotection through mitophagy 18. Fasting, mitophagy, and aging
19. Mitophagy and Alcoholic and Fatty Liver disease 20. Mitochondrial
dynamics and quality control in alcohol-associated liver disease and liver
tumorigenesis 21. Mitophagy in Yeast 22. Sphingolipid metabolism in the
regulation of mitophagy: Implications in cancer therapy, immune cell
function and neurodegeneration 23. Formation of mitophagosomes 24.
Mitophagy in Hepatic Ischemia/Reperfusion 25. Future developments Author
index