Mixed Solvency Concept - Mansuk, Avinash;Narkhede, Kantilal;Harish, Lukkad
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In these investigation conventional piroxicam capsule has slow onset of action (45-60 min) and poor bioavailability (50-60%), and therefore cannot be given in emergency clinical situations like postoperative pain, rheumatoid arthritis or osteoarthritis. So purpose of research was to provide a fast dissolving dosage form of piroxicam, which can provide quick onset of action by using mixed solvency concept. First carried out Initially solubility of piroxicam was determined individually in 3 hydrotropic agents like sodium benzoate, sodium citrate, niacinamide and 4 water soluble polymer namely…mehr

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Produktbeschreibung
In these investigation conventional piroxicam capsule has slow onset of action (45-60 min) and poor bioavailability (50-60%), and therefore cannot be given in emergency clinical situations like postoperative pain, rheumatoid arthritis or osteoarthritis. So purpose of research was to provide a fast dissolving dosage form of piroxicam, which can provide quick onset of action by using mixed solvency concept. First carried out Initially solubility of piroxicam was determined individually in 3 hydrotropic agents like sodium benzoate, sodium citrate, niacinamide and 4 water soluble polymer namely HPBCD, PVP K30, PEG400, PEG8000 at conc. of 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoate solution. Then different combinations of 2, 3 and 4 hydrotropic agents+water soluble polymer in different ratios were used to determine solubility, so that total conc. of solubilizer blend was always 40%. Highest solubility was obtained in solution of sodium benzoate+HP-BCD+PVP K30 at optimum ratio of 15:15:10. This optimized combination was utilized in preparing solid dispersions having enhanced solubility & used for pharmaceutical formulations.
Autorenporträt
Mr. Avinash G. Mansuk, completed his M.pharmacy in Pharmaceutics from university of pune. Author has participated in several national and international conference. Author has several national & international publications. Author have experience of teaching in reputed pharmacy college.