David A. Jans
MOBILE RECEPTOR HYPOTHESIS 199
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David A. Jans
MOBILE RECEPTOR HYPOTHESIS 199
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Produktdetails
- Neuroscience Intelligence Unit
- Verlag: Springer, Berlin
- 1997.
- Seitenzahl: 224
- Erscheinungstermin: Mai 1997
- Englisch
- Gewicht: 1g
- ISBN-13: 9780412132810
- ISBN-10: 0412132818
- Artikelnr.: 27622112
1. Introduction to the Mobile Receptor Hypothesis.- A. The Fluid Mosaic Model of Biological Membranes.- B. The Mobile Receptor Hypothesis.- C. Modern Collision Coupling Theory.- D. Summary and Implications.- 2. Direct Measurement of Lateral Mobility.- A. Introduction.- B. Fluorescence Microscopy.- C. Confocal Microscopy.- D. Fluorescence Photobleaching Recovery.- E. Lateral Mobility in the Cytoplasm and Membranes of Living Cells.- F. Measurements in Artificial and Isolated Membranes.- G. Measurements of Lateral Mobility Using Other Methods.- H. Summary.- 3. Parameters Affecting Plasma Membrane Protein Lateral Mobility.- A. Mechanisms of Protein Immobilization in Biological Membranes.- B. Membrane Lipid Mobility.- C. The Cytoskeleton.- D. Anchorage Modulation.- E. Membrane Protein Sequence Motifs.- F. Domain Structure: Regions of Restricted Mobility.- G. Signal Transduction.- H. Summary.- 4. Lateral Mobility of Polypeptide Hormone Receptors and GTP-Binding Proteins.- A. Introduction.- B. Practical Considerations.- C. Lateral Mobility Measurements of Polypeptide Hormone Receptors.- D. Tyrosine Kinase Receptor-Mediated Signal Transduction.- E. GTP-Binding Protein Activating Receptor-Mediated Signal Transduction.- F. Structural Considerations.- G. Lateral Mobility Measurements of GTP-Binding Proteins.- H. Lateral Mobility of Cytokine Receptors.- I. Summary and Implications for Signal Transduction.- 5. Evidence for the Role of Membrane Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- A. Introduction.- B. Kinetic Considerations in GTP-Binding Protein-Mediated Receptor-Effector Systems.- C. Indirect Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- D. Direct Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- E. Ga Signaling in the Cytosolic Phase.- F. Stoichiometric Considerations and Trimeric GTP-Binding Protein Immobility.- G.
1. Introduction to the Mobile Receptor Hypothesis.- A. The Fluid Mosaic Model of Biological Membranes.- B. The Mobile Receptor Hypothesis.- C. Modern Collision Coupling Theory.- D. Summary and Implications.- 2. Direct Measurement of Lateral Mobility.- A. Introduction.- B. Fluorescence Microscopy.- C. Confocal Microscopy.- D. Fluorescence Photobleaching Recovery.- E. Lateral Mobility in the Cytoplasm and Membranes of Living Cells.- F. Measurements in Artificial and Isolated Membranes.- G. Measurements of Lateral Mobility Using Other Methods.- H. Summary.- 3. Parameters Affecting Plasma Membrane Protein Lateral Mobility.- A. Mechanisms of Protein Immobilization in Biological Membranes.- B. Membrane Lipid Mobility.- C. The Cytoskeleton.- D. Anchorage Modulation.- E. Membrane Protein Sequence Motifs.- F. Domain Structure: Regions of Restricted Mobility.- G. Signal Transduction.- H. Summary.- 4. Lateral Mobility of Polypeptide Hormone Receptors and GTP-Binding Proteins.- A. Introduction.- B. Practical Considerations.- C. Lateral Mobility Measurements of Polypeptide Hormone Receptors.- D. Tyrosine Kinase Receptor-Mediated Signal Transduction.- E. GTP-Binding Protein Activating Receptor-Mediated Signal Transduction.- F. Structural Considerations.- G. Lateral Mobility Measurements of GTP-Binding Proteins.- H. Lateral Mobility of Cytokine Receptors.- I. Summary and Implications for Signal Transduction.- 5. Evidence for the Role of Membrane Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- A. Introduction.- B. Kinetic Considerations in GTP-Binding Protein-Mediated Receptor-Effector Systems.- C. Indirect Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- D. Direct Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- E. Ga Signaling in the Cytosolic Phase.- F. Stoichiometric Considerations and Trimeric GTP-Binding Protein Immobility.- G.