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Bacteria like Escherichia coli and Salmonella Typhimurium use flagella for locomotion. Each flagellum is run by a motor located in the cell body, with a long slender filament of 0.01-0.015mm long and 20nm in diameter attached to this motor. A swimming bacterium has all its filaments helical in shape involving a frequent change of their chirality, pitch and radius. To explain polymorphism, a new coarse-grained continuum rod theory with two molecular switches based on the quaternary structure of the filament is proposed. A phase diagram for filament shapes is calculated and the response of a…mehr

Produktbeschreibung
Bacteria like Escherichia coli and Salmonella
Typhimurium use flagella for locomotion. Each
flagellum is run by a motor located in the cell body,
with a long slender filament of 0.01-0.015mm long
and 20nm in diameter attached to this motor. A
swimming bacterium has all its filaments helical in
shape involving a frequent change of their chirality,
pitch and radius. To explain polymorphism, a new
coarse-grained continuum rod theory with two
molecular switches based on the quaternary structure
of the filament is proposed. A phase diagram for
filament shapes is calculated and the response of a
filament to external moment and force is examined. To
study the dynamics of the propagation of polymorphism
in the filaments, a toy model with an external
tensile shear fluid flow applied to a bistable
cantilever 1D rod was modeled on the lines of phase
transitions and simulations is performed using finite
element techniques. Interesting results like
nucleation of high-strain phase leading to either a
trapped front separating two phases or uniform
high-strain phase at steady state are observed.
Autorenporträt
Srikanth Srigiriraju received his Doctorate in Engineering in the
discipline of Solid Mechanics from Brown University where he
focused on the modeling of mechanics of bacterial flagella. He
also received a Masters from Brown University in Applied
Mathematics and a Bachelors in Mechanical Engineering from Indian
Institute of Technology, Madras.