Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs - Aland, Gourishankar
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Peptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid…mehr

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Produktbeschreibung
Peptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid gem-dimethyl group, imposing a pre-organized conformation favorable for complex formation with cDNA. In this regard, gem-dimethyl functionality need to be explored more by introducing in aminoethyl segment or aminoethyl and glycine, both segments. Also, significant stabilization of DNA:PNA hybrids occurs upon complexation with gold nanoparticles. It is shown here that the non-thiolic polyanionic DNAcan act as a template for organizing lysine capped cationic gold nanoparticles into linear superstructures. These types of assemblies may have potential for creating nanowires and lithographic circuits.
Autorenporträt
Dr. Gourishankar, Associate Professor, STES's SKNCOP, India, had received M.Pharm. (Pharm Chem.) and Ph.D. in Biotechnology (NCL-CSIR) from UoP, Pune. He was DBT-Post-Doc Fellow at NCBS-TIFR, India. His research has been supported by grants from DST & UoP and published in peer-reviewed journals. His research interest is in area of nanotherapeutics.