The result of the analysis of morphological, isozyme, RAPD and other PCR based molecular marker have been report to survey the genetic diversity among bread wheat germplasm collected from various geographical regions. Transmission of wheat to Asia through three routes was traced out by the analysis of Asian wheat landraces with isozyme and RAPD, and it was suggested that Asian wheat could be divided into at least three lineage. Quality related genes of wheat is genetically and geographically differentiated, alleles (HMW, LMW, puroindoline and waxy ) are geographically distributed. Some unique alleles are found in this study could be utilized to improve the quality of wheat proteins.