- The first text to show how an understanding of the molecular processes underpinning cancer can be directly applied to the development of new therapeutics, giving students a clear appreciation of how the theory relates to real life scenarios
- Provides a carefully structured overview of the molecular mechanisms that regulate cell replication, and relates defects in these mechanisms to the onset of cancer, so that students can clearly see the link between the two
- Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student; clarity is not sacrificed to achieve a contemporary account of the field
- Companion web site features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources
The Molecular Basis of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer. It shows how the malfunction of normal molecular pathways and components lead to cancer, and how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
Contents
- 1 Introduction
- 2 DNA Structure and Stability: Mutations vs. Repair
- 3 Regulation of Gene Expression
- 4 Growth Factor Signaling and Oncogenes
- 5 Growth Inhibition and Tumor Suppressor Genes
- 6 Apoptosis
- 7 Stem Cells and Differentiation
- 8 Metastasis
- 9 Nutrients, Hormones, and Gene Interactions
- 10 Cancer in the Future: Focus on Diagnostics and Immunotherapy
- Provides a carefully structured overview of the molecular mechanisms that regulate cell replication, and relates defects in these mechanisms to the onset of cancer, so that students can clearly see the link between the two
- Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student; clarity is not sacrificed to achieve a contemporary account of the field
- Companion web site features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources
The Molecular Basis of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer. It shows how the malfunction of normal molecular pathways and components lead to cancer, and how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
Contents
- 1 Introduction
- 2 DNA Structure and Stability: Mutations vs. Repair
- 3 Regulation of Gene Expression
- 4 Growth Factor Signaling and Oncogenes
- 5 Growth Inhibition and Tumor Suppressor Genes
- 6 Apoptosis
- 7 Stem Cells and Differentiation
- 8 Metastasis
- 9 Nutrients, Hormones, and Gene Interactions
- 10 Cancer in the Future: Focus on Diagnostics and Immunotherapy