Molecular Biology of Neurodegenerative Diseases: Visions for the Future

Herausgegeben:Teplow, David B.

• Gebundenes Buch

Produktbeschreibung

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more.

Produktdetails

• Progress in Molecular Biology and Translational Science Volume 168
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: S1877-1173(19)X0009-5
• Englisch
• Abmessung: 22mm x 152mm x 229mm
• Gewicht: 790g
• ISBN-13: 9780128178744
• Artikelnr.: 56758864

Inhaltsangabe

Section I: TARGETTING AD

1. Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings



Kaj Blennow and Henrik Zetterberg



2. Tracking down a missing trigger for Alzheimer's disease by mass spectrometric imaging based on brain network analysis



Minako Hoshi



3. Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid ß-protein



Ariel J. Kuhn and Jevgenij A. Raskatov



Section II: ETIOLOGY OF AD



4. In search of pathogenic amyloid ß-peptide in familial Alzheimer's disease



Michael S. Wolfe



5. Biology of splicing in Alzheimer's disease research



Kenichi Nagata, Takashi Saito, Takaomi C. Saido and Takashi Morihara



6. Acquired cerebral amyloid angiopathy: An emerging concept



Masahito Yamada, Tsuyoshi Hamaguchi and Kenji Sakai



Section III: NEUROIMMUNOLOGY OF AD



7. Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease



Goran Simic, Ena Spanic, Lea Langer Horvat and Patrick R. Hof



8. Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease



Susan Westfall, Umar Iqbal, Maria Sebastian and Giulio Maria Pasinetti



9. Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges?



Stefan Prokop, Virginia M.Y. Lee and John Q. Trojanowski



Section IV: AD THERAPY

10. Alzheimer's therapy development: A few points to consider



Einar M. Sigurdsson



11. The next steps in curing Alzheimer's disease



Fred W. van Leeuwen



12. Future horizons in Alzheimer's disease research



Thomas Wisniewski and Eleanor Drummond



13. Why delay in effective treatment for Alzheimer's disease and related conditions



Khalid Iqbal, Fei Liu, ChengXin Gong, Chunling Dai and Wen Hu



14. Restoring synaptic function through multimodal therapeutics



Raul Loera-Valencia, Muhammad-Al-Mustafa Ismail, Per Nilsson and Bengt Winblad



15. Disease-modifying therapy for proteinopathies: Can the exception become the rule?



Gal Bitan



16. Combination therapy for Alzheimer's disease and related dementias



Martin M. Bednar



Section V: ALPHA-SYNUCLEINOPATHIES



17. Can infections trigger alpha-synucleinopathies?



Christopher T. Tulisiak, Gabriela Mercado, Wouter Peelaerts, Lena Brundin and Patrik Brundin



18. Prion-like propagation of a-synuclein in neurodegenerative diseases



Airi Tarutani and Masato Hasegawa



Section VI: MODEL SYSTEMS



19. Yeast models of neurodegenerative diseases



Mick F. Tuite