H.E. Blum / C.H. Wu / G.Y. Wu (eds.)

Molecular Diagnosis and Gene Therapy

Herausgegeben:Blum, H. E.; Wu, C. H.; Wu, G. Y.

• Gebundenes Buch

Produktbeschreibung

Molecular diagnosis and gene therapy are of increasing interest and importance in clinical medicine. The increasing understanding of the pathogenesis of human diseases at the molecular level opens new perspectives for their diagnosis, prevention and therapy. The first part of this book, the proceedings of Falk Symposium No. 88 'Molecular Diagnosis and Gene Therapy', held in Basel, Switzerland, October 22-23, 1995, is aimed at an in-depth understanding of the methodology of molecular diagnosis by hybridization analysis, polymerase chain reaction and others. Further, the applications and limitations of these technologies in clinical medicine for the detection of genetic, malignant and infectious diseases are reviewed.
In the second part of the book, the basic strategies of gene therapy are presented, including gene transfer and targeting. Further, experimental and clinical applications of gene therapy strategies for the prevention and treatment of hepatic and other diseases are presented.
Molecular diagnosis and gene therapy are clearly going to be key elements of clinical medicine after the year 2000. In this sense, the book should allow basic scientists as well as clinicians to be informed about the state-of-the-art of molecular diagnosis and gene therapy and should provide a perspective for future developments in molecular medicine.

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Produktdetails

• Falk Symposium 88
• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 978-0-7923-8702-2
• 1996.
• Seitenzahl: 152
• Erscheinungstermin: 30. Juni 1996
• Englisch
• Abmessung: 234mm x 156mm x 11mm
• Gewicht: 413g
• ISBN-13: 9780792387022
• ISBN-10: 0792387023
• Artikelnr.: 23074577

Inhaltsangabe

Preface. Section I: Molecular Diagnosis. 1. Hybridization Analyses and
Polymerase Chain Reaction; K.A. Gutekunst. 2. Direct Quantification of
Viral Nucleic Acids Using Branched DNA (bDNA) Signal Amplification:
Methodology and Studies on Monitoring Chronic Viral Infections; J.C.
Wilber. 3. Diagnosis of Malignant Disease; D. Sidransky. 4. Molecular
Diagnosis and Characterization of Infectious Diseases and Novel Infectious
Agents; T.J. Liang. Section II: Gene Therapy: Basic Strategies. 5. Basic
Strategies for Gene Therapy: Gene Replacement and Augmentation; C.
Koch-Brandt. 6. Antisense Oligonucleotides as Therapeutic Agents; S.
Agrawal, R.P. Iyer. 7. Hepatocyte Transplantation for Metabolic Support and
Ex Vivo Gene Therapy; N.R. Chowdhury, et al. Section III: Gene Therapy:
Gene Transfer Strategies. 8. Retrovirally-Mediated Gene Transfer in
Medicine; W.H. Gunzburg. 9. Generation of AAV Vectors for Transduction and
Expression in Neuronal Cells in Vivo; R.J. Samulski. 10. Receptor-Mediated
Gene Delivery; M. Cotten, et al. 11. The Proton Sponge: A Trick the Viruses
Didn't Exploit; B.A. Demeneix, et al. Section IV: Gene Therapy for Hepatic
Diseases. 12. Gene Therapy for Hepatic Diseases; G.Y. Wu, C.H. Wu. 13.
Application of Ribozymes for Gene Therapy of Liver Disease in
Alpha1-Antitrypsin Deficiency; I. Ozaki, et al. 14. Crigler-Najjar Syndrome
and the Jaundiced Gunn Rat: Model Diseases for the Evaluation of Novel
Molecular and Cellular Therapies; P.D. Berk, et al. Section V: Gene
Therapy: Clinical Trials. 15. Cystic Fibrosis Gene Therapy Trials &endash;
Has Hepatobiliary Disease been Forgotten? A.M. Douar, C. Coutelle. Index.