Radha Mahendran, Suganya Jeyabaskar

Molecular Docking Studies on NarK2, NarX, HspX and DosR proteins

Bioinformatics Analysis and Prediction of Anti-tuberculosis Natural compounds

• Broschiertes Buch

Produktbeschreibung

Tuberculosis (TB) is a bacterial infection which spreads through the lymph nodes and blood stream and it mainly affects the lungs. TB is mainly caused by the bacterial pathogen, Mycobacterium tuberculosis which spreads infection from one person to another through tiny droplets released into the air via cough and sneezes. Most of the people who were exposed to TB never developed symptoms in their early stages, because the Mycobacterium tuberculosis survives in an inactive form in the body for the longer period. Through literature survey, four persistence tuberculosis proteins were identified and they were also found to possess drug resistance towards currently available synthetic tuberculosis drugs. Current study focuses on few natural anti-tuberculosis compounds from various plants which possess potential inhibitory activity against multi-drug resistant TB. Further they were screened for its druglikness properties using Lipinski rule of five. The compounds which satisfied the rule were further subjected to docking studies with four persistent tuberculosis proteins. The result of the docking studies revealed the inhibitory mechanism of the compounds towards the target proteins.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 92
• Erscheinungstermin: 13. April 2018
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 155g
• ISBN-13: 9786139817597
• ISBN-10: 6139817595
• Artikelnr.: 52543564

Autorenporträt

Dr.Radha Mahendran, trabalhando como Professor & Chefe, Departamento de Bioinformática, Vels Institute of Science, Technology and Advanced Studies. A área de especialização é Bioinformática, Microbiologia e Genética. Experiência de Ensino - 16 anos. Publicou vários artigos em várias revistas de renome.