Jorunn Litlekalsoy

Broschiertes Buch

Molecular investigations on archival tissues

Analysis of autopsies and biopsies from urinary bladder cancer collected since 1932

Beschreibung

Nowadays there are many available molecular methods
for studying diseases. Archival tissue provides an
extremely valuable material for proper understanding
of pathology of various diseases. A major problem in
molecular analysis of archival tissues is the tissue
degradation that might occur during long storage.
This monograph presents various methods for
efficient extraction of DNA and protocols for
sequencing (detection of gene mutations) from
archival tissues. It also provides protocols for
immunodetection of various proteins on such archival
tissues collected at Gades Institute, Haukeland
University Hospital, Norway in the period 1932 till
1996. In addition this book illustrates the value of
studies on archival tissues for detecting changes in
the pathogenesis of diseases with time. In this
monograph bladder cancer is used as an example for
such studies. This book could be useful for
professionals, considering the use of archival
tissue to study mechanisms of various diseases.

Autor

Jorunn Litlekalsoy is educated as engineer in analytical
chemistry at Norwegian High School of Engineering. She
obtained an MPhil in Molecular Biology at University of Bergen
in 2005 on establishing methods for molecular analysis of
archival tissue stored at Gades Institute. She is continuing
this work in a PhD study at Gades Institute.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 104
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 174g
• ISBN-13: 9783639168471
• ISBN-10: 363916847X
• Artikelnr.: 26539383