Krzysztof Wrzesinski

Molecular Markers Associated with Hepatotoxicity

Development of in vitro test system based on human cells

• Broschiertes Buch

Produktbeschreibung

Pharmaceutical and, to a lesser degree, most other
consumer products are routinely tested for safety.
Traditionally preclinical toxicological studies are
performed on animals. Metabolism of drugs and toxic
compounds in many cases is different in test animals
and humans. As a consequence results of toxicological
studies in animals can lead to false conclusions and
termination of development of drug candidates
potentially beneficial to humans and also to
continued development of drug candidates that later
show to be toxic to humans. This book presents
development of an in vitro human cells based test
system that is suitable for pre-clinical studies of
drugs and assessment of adverse effects of various
chemical compounds. The system is based on rotary
vessels that simulate growth in microgravity
conditions allowing the cells to grow continuously
for months and create cell conglomerates that
resemble normal liver tissue. Testing of drugs can be
performed for hours or weeks/months to follow acute
or chronic toxicity respectively.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 208
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783639167559
• ISBN-10: 3639167554
• Artikelnr.: 26604805

Autorenporträt

Krzysztof Wrzesinski graduated from the Agricultural University
of Wroclaw, Poland. During his PhD and Postdoctoral fellowship
he worked at the University of Southern Denmark, Odense, Denmark
establishing human in vitro systems for pre-clinical development
of drugs and toxicological assessment of chemical compounds.