The growing body of information on bacteria pathogenic for humans, mammals and plants generated within the past ten years has shown the interesting conservation of newly identified genes that playa direct role in the pathogenic mechanism. In addition to these genes, there are also genes that confer host specificities and other traits important in pathogenesis on these pathogens. In this volume, we have organized the subject areas to best fit the concept on the way bacterial pathogens recognize, interact and invade the host, on the regulation of genes involved in virulence, on the genes…mehr
The growing body of information on bacteria pathogenic for humans, mammals and plants generated within the past ten years has shown the interesting conservation of newly identified genes that playa direct role in the pathogenic mechanism. In addition to these genes, there are also genes that confer host specificities and other traits important in pathogenesis on these pathogens. In this volume, we have organized the subject areas to best fit the concept on the way bacterial pathogens recognize, interact and invade the host, on the regulation of genes involved in virulence, on the genes involved in the elaboration of toxins and other pathogenic components such as iron sequestering proteins, and on the mechanisms of circumventing the host defense systems. These areas are divided into Sections. Section I covers the first step when the pathogen seeks its host, and Sections II through VI cover subsequent steps leading to pathogenesis while avoiding host defenses. We conclude this workwith a chapter summarizing information on examples of virulence mechanisms that are highly conserved.
I. Host Recognition and Attachment Mechanisms.- 1. Phenotypic and Genetic Aspects of Host Cell Invasion by Salmonella Species.- 2. CS1 Pili of Enterotoxigenic E. coli.- 3. Molecular Escorts Required to Present Bacterial Adhesins to Eukaryotic Receptors.- 4. Studies on the Pili of Promiscuous Plasmid RP4.- 5. Fimbria (pilus) Mediated Attachment of Pseudomonas syringae, Erwinia rhapontici and Xanthomonas campestris to Plant Surfaces.- 6. Attachment of Agrobacterium tumefaciens to Hosts Cells.- 7. The Function and Regulation of Genes Required for Extracellular Polysaccharide Synthesis and Virulence in Pseudomonas solanacearum.- 8. Effects of Opa proteins, and Lipooligosaccharides on Surface Charge and Biological Behavior of Gonococci.- 9. Anthrax Toxin Mechanisms of Receptor Binding and Internalization.- 10. Host-specific Virulence Genes of Xanthomonas.- II. Pathogen Ingression and Invasive Mechanisms.- 11. Iron and Plant Pathogenesis: the Systemic Soft Rot Disease Induced by Erwinia chrysanthemi 3937 on Saintpulia Plants.- 12. Characterization of the Vibrio cholerae Heme Iron Transport System and its Role in Pathogenesis.- 13. Toxin Secretion in Bordetella pertussis: Breaking the Gram-negative Barrier.- 14. Factors affecting the Virulence of Soft Rot Erwinia Species: the Molecular Biology of an Opportunistic Phytopathogen.- 15. Processing of the T-DNA from the Agrobacterium tumefaciens Ti-plasmid.- 16. T-DNA Transfer from Agrobacterium to the Plant Cell Nucleus.- 17. Mechanisms of T-DNA Transfer and Integration into Plant Chromosomes: Role of virB, virD4 and virE2 and a Short Interspersed Repetitive Element (SINE) from Tobacco.- 18. Molecular Pathogenesis of Viridans Streptococcal Endocarditis.- 19. Method for Detecting Gene Expression of Internalized Salmonella typhimurium in Macrophages.- III. Elaboration of Pathogenic Factors.- 20. Structural and Functional Analysis of HpmA Hemolysin of Proteus mirabilis.- 21. Assembly of Escherichia coli Heat-Labile Enterotoxin and Its Secretion from Vibrio cholerae.- 22. Extracellular Virulence Factors of Pseudomonas solanacearum: Role in Disease and Regulation of Expression.- 23. RTX-toxins in Actinobacillus pleuropneumoniae and Their Potential Role in Virulence.- 24. Capsular Polysaccharide Production in Erwinias.- 25. The Role of Extracellular Polysaccharides as Virulence Factors for Phytopathogenic Pseudomonads and Xanthomonads.- 26. Transcriptional Regulation of ?-hemolysin Genetic Expression: hly M, a Sequence Contained in hlyC, Modulates Hemolysin Transcription.- 27. The Role of the syrBCD Gene Cluster in the Biosynthesis and Secretion of Syringomycin by Pseudomonas syringae pv. syringae.- 28. Characterization of Genes involved in Phaseolotoxin Production and its Thermal Regulation.- 29. Application of Capillary Liquid Chromatography-Electrospray Mass Spectrometry to Identify Major Siderophores of Erwinia amylovora as Proferrioxamines and Their Potential Role in Virulence.- IV. Regulation of Virulence Genes and Signal Transduction.- 30. Transcriptional Elements in Pasteurella haemolytica Leukotoxin Expression.- 31. Signal Transduction in Yersinia pseudotuberculosis.- 32. Regulation of Agrobacterium tumefaciens Virulence Gene Expression.- 33. Regulation of the Iron Transport Genes Encoded by the pJMI Virulence Plasmid in Vibrio anguillarum.- 34. Conservation of the lemA Gene, a Virulence Regulator from the Plant Pathogen Pseudomonas syringae, within a Human Pathogenic Bacterium.- 35. Virulence Regulation of Bordetella pertussis.- 36. Regulation of Shigella Virulence Expression.- 37.Molecular Genetic Analysis of Global Regulation of Extracellular Enzyme Synthesis in Erwinia carotovora subspecies carotovora.- V. Mechanisms Against Host Defenses.- 38. Physiology of Resistant Interactions between Xanthomonas oryzae pv. Oryzae and Rice.- 39. Mechanisms for the Virulence of Norcardia.- 40. Developments in the Interaction of Bacterial Avirulence Genes and Plant Disease Resistance Genes.- 41. Anti-Host-Defense Systems are Elaborated by Plant Pathogenic Bacteria.- 42. Organization, Regulation, and Function of Pseudomonas syringae pv. syringae hrp Genes.- 43. The Role of Indoleacetic Acid Production of Pseudomonas syringae Pathovars in their Pathogenicity on Host Plants.- 44. Molecular Analysis of Virulence Associated Gene Regions from the Ovine Footrot Pathogen, Dichelobacter nodosus.- 45. Genes Governing the Secretion of Factors Involved in Host-Bacteria Interactions are Conserved Among Animal and Plant Pathogenic Bacteria.- 46. Defining the Contribution of the Agrobacterium Chromosome in Crown Gall Tumorgenesis.
I. Host Recognition and Attachment Mechanisms.- 1. Phenotypic and Genetic Aspects of Host Cell Invasion by Salmonella Species.- 2. CS1 Pili of Enterotoxigenic E. coli.- 3. Molecular Escorts Required to Present Bacterial Adhesins to Eukaryotic Receptors.- 4. Studies on the Pili of Promiscuous Plasmid RP4.- 5. Fimbria (pilus) Mediated Attachment of Pseudomonas syringae, Erwinia rhapontici and Xanthomonas campestris to Plant Surfaces.- 6. Attachment of Agrobacterium tumefaciens to Hosts Cells.- 7. The Function and Regulation of Genes Required for Extracellular Polysaccharide Synthesis and Virulence in Pseudomonas solanacearum.- 8. Effects of Opa proteins, and Lipooligosaccharides on Surface Charge and Biological Behavior of Gonococci.- 9. Anthrax Toxin Mechanisms of Receptor Binding and Internalization.- 10. Host-specific Virulence Genes of Xanthomonas.- II. Pathogen Ingression and Invasive Mechanisms.- 11. Iron and Plant Pathogenesis: the Systemic Soft Rot Disease Induced by Erwinia chrysanthemi 3937 on Saintpulia Plants.- 12. Characterization of the Vibrio cholerae Heme Iron Transport System and its Role in Pathogenesis.- 13. Toxin Secretion in Bordetella pertussis: Breaking the Gram-negative Barrier.- 14. Factors affecting the Virulence of Soft Rot Erwinia Species: the Molecular Biology of an Opportunistic Phytopathogen.- 15. Processing of the T-DNA from the Agrobacterium tumefaciens Ti-plasmid.- 16. T-DNA Transfer from Agrobacterium to the Plant Cell Nucleus.- 17. Mechanisms of T-DNA Transfer and Integration into Plant Chromosomes: Role of virB, virD4 and virE2 and a Short Interspersed Repetitive Element (SINE) from Tobacco.- 18. Molecular Pathogenesis of Viridans Streptococcal Endocarditis.- 19. Method for Detecting Gene Expression of Internalized Salmonella typhimurium in Macrophages.- III. Elaboration of Pathogenic Factors.- 20. Structural and Functional Analysis of HpmA Hemolysin of Proteus mirabilis.- 21. Assembly of Escherichia coli Heat-Labile Enterotoxin and Its Secretion from Vibrio cholerae.- 22. Extracellular Virulence Factors of Pseudomonas solanacearum: Role in Disease and Regulation of Expression.- 23. RTX-toxins in Actinobacillus pleuropneumoniae and Their Potential Role in Virulence.- 24. Capsular Polysaccharide Production in Erwinias.- 25. The Role of Extracellular Polysaccharides as Virulence Factors for Phytopathogenic Pseudomonads and Xanthomonads.- 26. Transcriptional Regulation of ?-hemolysin Genetic Expression: hly M, a Sequence Contained in hlyC, Modulates Hemolysin Transcription.- 27. The Role of the syrBCD Gene Cluster in the Biosynthesis and Secretion of Syringomycin by Pseudomonas syringae pv. syringae.- 28. Characterization of Genes involved in Phaseolotoxin Production and its Thermal Regulation.- 29. Application of Capillary Liquid Chromatography-Electrospray Mass Spectrometry to Identify Major Siderophores of Erwinia amylovora as Proferrioxamines and Their Potential Role in Virulence.- IV. Regulation of Virulence Genes and Signal Transduction.- 30. Transcriptional Elements in Pasteurella haemolytica Leukotoxin Expression.- 31. Signal Transduction in Yersinia pseudotuberculosis.- 32. Regulation of Agrobacterium tumefaciens Virulence Gene Expression.- 33. Regulation of the Iron Transport Genes Encoded by the pJMI Virulence Plasmid in Vibrio anguillarum.- 34. Conservation of the lemA Gene, a Virulence Regulator from the Plant Pathogen Pseudomonas syringae, within a Human Pathogenic Bacterium.- 35. Virulence Regulation of Bordetella pertussis.- 36. Regulation of Shigella Virulence Expression.- 37.Molecular Genetic Analysis of Global Regulation of Extracellular Enzyme Synthesis in Erwinia carotovora subspecies carotovora.- V. Mechanisms Against Host Defenses.- 38. Physiology of Resistant Interactions between Xanthomonas oryzae pv. Oryzae and Rice.- 39. Mechanisms for the Virulence of Norcardia.- 40. Developments in the Interaction of Bacterial Avirulence Genes and Plant Disease Resistance Genes.- 41. Anti-Host-Defense Systems are Elaborated by Plant Pathogenic Bacteria.- 42. Organization, Regulation, and Function of Pseudomonas syringae pv. syringae hrp Genes.- 43. The Role of Indoleacetic Acid Production of Pseudomonas syringae Pathovars in their Pathogenicity on Host Plants.- 44. Molecular Analysis of Virulence Associated Gene Regions from the Ovine Footrot Pathogen, Dichelobacter nodosus.- 45. Genes Governing the Secretion of Factors Involved in Host-Bacteria Interactions are Conserved Among Animal and Plant Pathogenic Bacteria.- 46. Defining the Contribution of the Agrobacterium Chromosome in Crown Gall Tumorgenesis.
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