Design, Syntheses and Molecular Modeling studies on Anti-HIV and Anti-HBV nucleosides with special focus on understanding the underlying mechanism of their action as well as inaction. A better understanding of their mechanism will help facilitate the better designing of novel drugs to combat against them. Molecular modeling as well as Molecular Dynamics studies were conducted to ascertain their mode of binding and calculate their binding affinities and to find a correlation between their binding affinities and their biological activity.
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