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DENV is the most important factors transmitted by mosquitoes worldwide causing viral disease, almost 100 million cases of dangerous DENV each year, resulting in severe and life-threatening. However, we have not completed a comprehensive outlook of all miRNAs expression regulation target genes through virus-human interactions in patients of DENV. A few human miRNAs might show antiviral miRNAs. When some delusive antiviral miRNAs were blocked by locked nucleic acid-modified antisense oligoribonucleotides, the hosts miss carriage to suppress viral replication.