Molecular Optimization of Calcineurin Inhibitors for Prion Disease - Patel, Saumya;Kumar, S.Prasanth;Jasrai, Yogesh T.
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This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.

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Produktbeschreibung
This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.
Autorenporträt
Saumya K. Patel, a budding Bioinformatician engaged in development of antimalarial and anticancer compounds and proves its efficacy in wet-lab experiments. He chosen his career in Ph.D. Bioinformatics after the completion of graduation in Biochemistry and post-graduation in Bioinformatics.He has also published research articles in reputed journals.