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A Neuro-bioinformatics approach has been utilized in remodeling previously predicted structures and modeling newly identified proteins structures in which mutations are responsible for causing NSMR. Modeling Neuropeptides whose truncation is responsible for causing NSMR is a chief aspect of the project. Subsequent results led to major findings, potentially an important cognitive pathway in the human brain. Utilizing prior knowledge and amalgamating it with our set scheme of experimentation and acquired knowledge led to some events important to neuronal or synaptic plasticity never seen, sighted and reported before.