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Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject. Monoclonal antibodies provide highly specific reagents with which to identify, analyse, quantitate and manipulate molecules - both in solution and in solid phase, such as at a cell surface. The aim of this book is therefore to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies in many areas of clinical medicine, including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology and dermatology.
Table of contents:
1. Introduction; 2. Production of monoclonal antibodies; 3. Antigen-antibody interactions: how affinity and kinetics affect assay design and selection procedures; 4. The production and characterisation of synthetic peptide-derived antibodies; 5. Human monoclonal antibodies; 6. Bispecific monoclonal antibodies; 7. The production of antibodies using phage display libraries; 8. Genetic manipulation of monoclonal antibodies; 9. Monoclonal antibodies in diagnostic immunoassays; 10A. Monoclonal antibodies in diagnostic pathology; 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies; 11A. Monoclonal antibodies in infectious disease: diagnosis; 11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease; 12A. Monoclonal antibodies in transplantation: immunohistology; 12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression; 12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation; 12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation; 13. Monoclonal antibodies and the skin; 14. Monoclonal antibodies in endocrinology; 15. Monoclonal antibodies in rheumatology; 16. Technical appendix.
Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.
Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.
Table of contents:
1. Introduction; 2. Production of monoclonal antibodies; 3. Antigen-antibody interactions: how affinity and kinetics affect assay design and selection procedures; 4. The production and characterisation of synthetic peptide-derived antibodies; 5. Human monoclonal antibodies; 6. Bispecific monoclonal antibodies; 7. The production of antibodies using phage display libraries; 8. Genetic manipulation of monoclonal antibodies; 9. Monoclonal antibodies in diagnostic immunoassays; 10A. Monoclonal antibodies in diagnostic pathology; 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies; 11A. Monoclonal antibodies in infectious disease: diagnosis; 11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease; 12A. Monoclonal antibodies in transplantation: immunohistology; 12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression; 12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation; 12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation; 13. Monoclonal antibodies and the skin; 14. Monoclonal antibodies in endocrinology; 15. Monoclonal antibodies in rheumatology; 16. Technical appendix.
Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.
Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.