Ziad Haddad

Monocytic Cell Responses to Aspergillus Fumigatus

Investigation of Phagocytosis, Gene Expression and Peptide Presentation

• Broschiertes Buch

Produktbeschreibung

Aspergillus fumigatus is a member of a large genus offilamentous fungi found in the environment. It ispathogenic to humans, causing life-threateninginfections in immunocompromised patients, likeleukemia and bone-marrow transplant patients. Thisstudy was initiated to investigate a stilllittle-researched field in immune response againstthis pathogenic fungus: the role of monocytes.We therefore analyzed the interaction of Aspergillusfumigatus withhuman monocytes on different levels.We investigated Phagocytosis of fungal spores andperformed gene expression analysis using microarraygene chips. In a second effort we analyzed peptidespresented on monocytes upon interaction with the fungus.We could show monocytes to play a major role inphagocytosing fungal spores and that Asp. fumigatusinduces inflammatory response in monocytes, which maylead to lung injury, a phenomenon observed often inpatients with invasive aspergillosis.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 124
• Englisch
• Abmessung: 220mm
• Gewicht: 180g
• ISBN-13: 9783639069945
• ISBN-10: 3639069943
• Artikelnr.: 24877431

Autorenporträt

Dr. Ziad Haddad was born May 9th 1978 in Lebanon. Studiedbiochemistry at the university of Tuebingen, Germany. Finishedhis diploma thesis June 2003 and completed his PhD work inbiochemistry in June 2006 in Tuebingen. Now working as apharmaceutical consultant for psychiatric drugs in Germany.