Monosodium Glutamate (MSG): Plasma Prolactin Level In Male Rabbits - Adalat, Rooma;Sajjad, Sumera;Zahid, Lubna
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The present study was designed to demonstrate the effect of monosodium glutamate on PRL level in prepubertal rabbits. Glutamate is a major neurotransmitter that acts on extensive brain regions, such as hypothalamus and the pituitary and induce the secretion of PRL. In this study, young male rabbits (Lates calcarifer) of 3 to 4 months of age were treated with 2mg/g body weight MSG dissolved in 0.9% saline. The animals in control group received equal quantity of 0.9% saline. Blood samples were collected 15 minutes after administration of drug, and plasma was separated. All plasma samples were…mehr

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Produktbeschreibung
The present study was designed to demonstrate the effect of monosodium glutamate on PRL level in prepubertal rabbits. Glutamate is a major neurotransmitter that acts on extensive brain regions, such as hypothalamus and the pituitary and induce the secretion of PRL. In this study, young male rabbits (Lates calcarifer) of 3 to 4 months of age were treated with 2mg/g body weight MSG dissolved in 0.9% saline. The animals in control group received equal quantity of 0.9% saline. Blood samples were collected 15 minutes after administration of drug, and plasma was separated. All plasma samples were analyzed by Enzyme linked Immunosorbent Assay (ELISA). Within the control group, there was no significant difference in plasma PRL level (p0.05). In treated group, plasma PRL level was highest in T2 (2.69 ± 0.042 ng/ml) and lowest in T1 (2.16 ± 0.067 ng/ml). Administration of glutamate in the form of MSG causes tonic activation of tuberinfudibular dopaminergic neuron system (TIDA). As a resultdopamine release, PRL level in prepubertal rabbits decreases. Regression analysis of variance showed non significant negative trend in plasma PRL level (p 0.05) in animals of control and treated group.
Autorenporträt
Ms. Rooma Adalat completed BS (Hons.) and MS (Zoology) from Lahore College for Women University, Pakistan. She is currently pursuing Ph.D (Biotechnology and Microbiology) and has major interest in neuroendocrinology and biotechnology.