Cell to cell pursued to tissue transformation is highly commanded phenomenon that involves a string of event primarily aligned on different molecular and biochemical pathways. Many key regulator gene and vital checkpoints ensure toggled "on/off" various interactive proteins thereby successfully switch on/off the cell division. Non repairable genomic mutation by any means on a molecular level of cell cycle progression may impart the limitless replicative potential of the earmarked cell. Currently the assigned cell set off mitosis to form niche of tissue lump called primary tumor or neoplasm. Inappropriate over-expression of normal Oncogene and/or formation of novel Oncogene concurrently under-expression of tumor suppressor gene into the neo-plasmic niche imposed invasion quality besides sustainment of angiogenesis and self-sufficient growth signaling trait. Accordingly the neoplastic cell soon differentiated into secondary tumor, possessing a scope of spread from originating organ to distant place. The noticeable cell detached from its basement and unfastened cell to cell union, and became spindle shaped for dignifying its metastatic patrimony. In this time& age this malignant neoplasm is termed as "CANCER".