Premature infant is a live born infant delivered before 37 weeks from the first day of last menstrual period (LMP). Preterm birth is the most common cause of death among infants Worldwide. The preterm birth rate was estimated to be about 23% (range 5% in parts of Europe to 18% in parts of Africa), and about 15 million neonates are born preterm each year. As these, preterm births 84% occurred at 32 to 36 weeks of gestational age (GA), 10% occurred at 28 to less than 32 weeks GA and 5% occurred at less than 28 weeks GA, it represent the highest percentage of high-risk group and account for the largest number of admissions to the Neonatal Intensive Care Units (NICUs).Premature neonates are highly vulnerable group of the population. Premature births accounts for the highest mortality rate among infants in the first year of life.