A great attention has been placed on employee motivation and performance the world over. The public health sector presents unique challenges with respect to motivation and employee performance. Managers are often required to operate with limited resources and restrictions on the ability to replace employees. This study investigates the challenges of motivation of employees in the health delivery system of the public health sector of developing countries a case study of Harare Central Hospital. Employees are the life-blood of any organisation. Employee cooperation cannot be substituted by anything else. It is vital that employees are motivated to be assured of the achievement of the organisation's objectives. A motivated workforce is an asset that appreciates in value over time, thereby directly contributing to organisational performance. Good financial rewards were found to be necessary to influence the behaviour of employees so as to enhance organisational performance. Motivatedemployees are inspired and committed to the organisation. It was concluded that motivation strategies plays an important role in boosting the organisation's performance.