Advancement and the progress made by the pharmaceutical industry that greatly contributed to treat the diseases, thus improving the quality of life. With the passage of the time researchers who are involved in the drug development industries focus on the alternative routes of administration of potentially capable pharmaceutical products and as well as to overcome defects that are associated with the oral route of administration. Though oral route is the most preferred route for the administration of major drugs but it possess certain draw backs such as, the first pass metabolism in the liver, the local GI and enzymatic degradation inside the GI tracts.