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Multiple malignant primary tumours are rare in cancer patients; their frequency, as demonstrated by autopsies, has been between 3% and 3.6%. It is rare to find more than three distinct primary cancers in an individual. This is a retrospective descriptive study covering 2 years, 2022 and 2023, with a collection of 4 illustrative cases. The average age of the patients was 58. All patients had a good outcome. The synchronous tumour associations collected were: (breast and cervix, ovary and lung, endometrium and ovary, vulva and colon). Synchronous association of primary cancers requires a strict diagnostic approach in order to distinguish metastatic forms from primary forms for better patient management.