Stephen Waxman

Multiple Sclerosis as a Neuronal Disease

• Gebundenes Buch

Produktbeschreibung

Multiple sclerosis (MS) is an autoimmune disease that results in the destruction of the myelin sheath that surrounds nerve fibers of the brain, spinal cord, and optic nerves. As a result, the transmission of nerve impulses becomes impaired, particularly in pathways involved with vision, sensation, and movement. The disease primarily occurs in individuals between the ages of 20 and 40, and women are affected by the disease more often than men. The disease remains enigmatic, with some patients experiencing no symptoms or a remission of the disease in which previously impaired functions such as vision or motor skills are restored. Other patients experience a course characterized by worsening progress. This book examines the role of neurons in MS and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

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Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 496
• Erscheinungstermin: 22. April 2005
• Englisch
• Abmessung: 287mm x 225mm x 34mm
• Gewicht: 1841g
• ISBN-13: 9780127387611
• ISBN-10: 0127387617
• Artikelnr.: 21470706

Inhaltsangabe

PrefaceContributorsI Structure, Molecular Organization, and Function of
Myelinated Axons 1. The Structure of Myelinated Axons in the CNS 2.
Dialogues: Communication Between Axons and Myelinating Glia 3. Molecular
Specializations at the Glia-Axon Interface 4. Potassium Channel
Organization of Myelinated and Demyelinated Axons 5. The Roles of Potassium
and Calcium Channels in Physiology and Pathophysiology of AxonsII Neuronal
Concomitants of Demyelination 6. The Conduction Properties of Demyelinated
and Remyelinated Axons 7. Altered Distributions and Functions of Multiple
Sodium Channel Subtypes in Multiple Sclerosis and Its Models 8. Na+ Channel
Reorganization in Demyelinated Axons 9. Ion Currents and Axonal
Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms
in Multiple Sclerosis 10. Clinical Pharmacology of Abnormal Potassium
Channel Organization in Demyelinated AxonsIII Multiple Sclerosis as a
Neurodegenerative Disease 11. Pathology of Neurons in Multiple Sclerosis
12. Axonal Degeneration in Multiple Sclerosis: The Histopathological
Evidence 13. Natural History of Multiple Sclerosis: When Do Axons
Degenerate?IV Measurement of Neuronal Changes in the Clinical Domain 14.
Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection 15.
MRI-Clinical Correlations in Multiple Sclerosis: Implications for Our
Understanding of Neuronal Changes 16. Electrophysiological Correlates of
Relapse, Remission, Persistent Sensorimotor Deficit, and Long-Term Recovery
Processes in Multiple SclerosisV Cellular and Molecular Mechanisms of
Axonal Degeneration in Multiple Sclerosis 17. Inflammation and Axon
Degeneration 18. Nitric Oxide and Axonal Pathophysiology 19. Molecular
Mechanisms of Calcium Influx in Axonal Degeneration 20. Axonal Damage and
Neuron Death in Multiple Sclerosis and Experimental Autoimmune
Encephalomyelitis: The Role of Calpain 21. Mutations of
Myelination-Associated Genes That Affect Axonal IntegrityVI Other Aspects
of Neuronal Injury in Multiple Sclerosis 22. Neuronal Blocking Factors in
Demyelinating Diseases 23. Evidence for Neuronal Apoptosis in Demyelinating
CNS DiseasesVII Lessons from the Peripheral Nervous System 24. Mechanisms
Underlying Wallerian Degeneration 25. AMAN: What It Teaches Us about
Mechanisms Underlying Axonal Injury VIII Prognosis, Reparative Mechanisms,
and Therapeutic Approaches 26. Axonal Degeneration as a Predictor of
Outcome in Neurological Disorders 27. Remyelination as Neuroprotection 28.
Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated
Axons 29. Blocking the Axonal Injury Cascade: Neuroprotection in Multiple
Sclerosis and Its Models 30. Functional Brain Reorganization and Recovery
after Injury to White MatterIndex