A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as…mehr
A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.
Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit. Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure.
Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.
Inhaltsangabe
Part 1: Introduction
1. An Introduction to Muscle
2. A History of Muscle
Part II: Cardiac Muscle
Section A: Basic Physiology
3. Cardiac Myocyte Specification and Differentiation
4. Transcriptional Control of Cardiogenesis
5. Cardiomyocyte Ultrastructure
6. Overview of CArdiac Muscle Physiology
7. Ionic Fluxes and Genesis of the Cardiac Action Potential
8. G-Protein-Coupled Receptors in the Heart
9. Receptor Tyrosine Kinases in Cardiac Muscle
10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network
11. Calcium Fluxes and Homeostasis
12. Excitation-Contraction Coupling in the Heart
13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle
14. Cardiovascular Mechanotransduction
15. Cardiomyocyte Metabolism: All Is in Flux
16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function
17. Mitochondrial Morphology and Function
18. Genetics and Genomics in Cardiovascular Gene Discovery
19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications
Section B: Adaptations and Response
20. Adaption and Responses: Myocardial Innervations adn Neural Control
21. Regulation of Cardiac Systolic Function and Contractility
22. Intracellular Signaling Pathways in Cardiac Remodeling
23. Oxidative Stress and Cardiac Muscle
24. Physiologic and Molecular Responses of the Heart to Chronic Exercise
25. Epigenetics in Cardiovascular Biology
26. Cardiac MicroRNAs
27. Protein Quality Control in Cardiomyocytes
28. Cardioprotection
29. Cardiac Fibrosis: Cellular and Molecular Determinants
30. Autophagy in Cardiac Physiology and Disease
31. Programmed Cardiomyocyte Death in Heart Disease
32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation
Section C: Myocardial Disease
33. Congenital Cardiomyopathies
34. Genetics of Congenital Heart Disease
35. Mechanisms of Stress-Induced Cardiac Hypertrophy
36. Ischemic Heart Disease
37. The Pathophysiology of Heart Failure
38. The Right Ventricle: Reemergence of the Forgotten Ventricle
39. Mammalian Myocardial Regeneration
40. The Structural Basis of Arrhythmia
41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias
42. Genetic Mechanisms of Arrhythmia
43. Infiltrative adn Protein Misfolding Myocardial Diseases
44. Cardiac Aging: From Humans to Molecules
45. Adrenergic Receptor Polymorphisms in Heart Failure
46. Cardiac Gene Therapy
47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics
48. Cell Therapy for Cardiac Disease
49. Chemical Genetics of Cardiac Regeneration
50. Device Therapy for Systolic Ventricular Failure
51. Novel Therapeutic Targets and Strategies against Myocardial Diseases
Part III: Skeletal Muscle
Section A: Basic Physiology
52. Skeletal Muscle Development
53. Skeletal Muscle: Architecture of Membrane Systems
54. The Vertebrate Neuromuscular Junction
55. Neuromuscular Interactions that Control Muscle Function and Adaptation
56. Control of Resting CA2+ Concentration in Skeletal Muscle
61. Regulation of Skeletal Muscle Development and Function by microRNAs
62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects
63. Immunological Responses to Muscle Injury
64. Skele
Rezensionen
"This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe." --Reference & Research Book News October 2012
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