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Musculoskeletal disorder is a global term for several types of disorder affecting the neck, back, upper limbs or lower limbs. Numerous risk factors including occupational, individual and social factors are involved in the development of MSDs. This cross sectional analytical study was carried out among computer using employee of commercial banks of Pokhara Lekhnath Metropolitan City. Nordic standardized questionnaire was used to collect the data. Assessing the prevalence of MSD, 79 of the respondents have reported the symptoms of MSD in different body parts. Back, neck, shoulder and hip were the most affected body parts as per this study. Regarding the association of MSD with different factors, smoking (p-0.018), working hours (p-0.02), job satisfaction (p-0.001, prefer working in computer (p-0.000) and stressful job (p-0.007) showed significant association with MSD at 95% confidence level.