Kaminsky

Myasthenia Gravis and Related Disorders

11th International Conference, Volume 1022
Herausgeber: Kaminski, Henry J; Barohn, Richard

• Broschiertes Buch

Produktbeschreibung

Basic and clinical investigators have contributed reports to this volume in which they explore new findings in myasthenia gravis and related diseases, exploring topics in basic science, translational research, and clinical science, including advances in therapies and treatment strategies. Topics covered include the following: structure and function of the neuromuscular junction; communication between nerve and muscle; structure and function of the acetylcholine receptor; neuromuscular junction pathology; autoimmunity and signaling; immunology of autoimmune disorders involving the neuron and presynaptic nerve terminal; autoimmune pathogenesis of myasthenia gravis; clinical treatments including thymectomy; myasthenia gravis due to muscle-specific kinase antibodies. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Wiley
• Seitenzahl: 400
• Erscheinungstermin: 8. Juli 2008
• Englisch
• Abmessung: 259mm x 178mm x 18mm
• Gewicht: 835g
• ISBN-13: 9781573316873
• ISBN-10: 1573316873
• Artikelnr.: 22973679

Autorenporträt

Henry J. Kaminski, MD is board-certified in Neurology, the Meta Amalia Neumann professor, and the chair of the Department of Neurology at The George Washington University.

Inhaltsangabe

Preface: Henry J. Kaminski and Richard J. Barohn. Part I: Structure and Function of the Neuromuscular Junction:. 1. Structural Factors Influencing the Efficacy of Neuromuscular Transmission: Clarke Slater. 2. Cell to Cell Signaling at the Neuromuscular Junction: The Dynamic Role of the Extracellular Matrix: Michael Werle. 3. The Role of Glial Cells in the Formation and Maintenance of the Neuromuscular Junction: Zhihua Feng and Chien-Ping Ko. Part II: Structure and Function of the Acetylcholine Receptor:. 4. Myasthenia Gravis and the Tops and Bottoms of AChRs: Antigenic Structure of the MIR and Specific Immunosuppresssion of EAMG Using AChR Cytoplasmic Domains: Jon Lindstrom. 5. Functional Organization and Conformational Dynamics of the Nicotinic Receptor: A Plausible Structural Interpretation of Myasthenic Mutations: Antoine Taly and Jean Pierre Changeux. 6. Recent Structural and Mechanistic Insights into Endplate Acetylcholine Receptors: Steven M. Sine
Fan Gao
Won Yong Lee
Nuriya Mukhtasimova
Hai-Long Wang and Andrew G. Engel. 7. Peptide-Toxin Tools for Probing the Expression and Function of Fetal and Adult Subtypes of the Nicotinic Acetylcholine Receptor: Russell W. Teichert
Carmen C. Garcia
Joseph G. Potian
James J. Schmidt
Veit Witzemann
Baldomero M. Olivera
and Joseph J. McArdle. Part III: Muscle-Specific Kinase and Myasthenia Gravis:. 8. Clinical Phenotype of Muscle-Specific Tyrosine Kinase Antibody-Positive Myasthenia Gravis: Gil I. Wolfe and Shin J. Oh. 9. Response to Therapy in Myasthenia Gravis with Anti-MuSK Antibodies: Amelia Evoli
Maria R. BianchiI
Raffaella Riso
Giacomo M. Minicuci
Ana P. Batocchi
Serenella Servidei
Flavia Scuderi
and Emanuela Bartoccioni. 10. Antibodies in Myasthenia Gravis without Acetylcholine Receptor Antibodies: Angela Vincent
Maria Isabel Leite
Maria Elena Farrugia
Saiju Jacob
Stuart Viegas
Hiro Shiraishi
Olivier Benveniste
Paul Morgan
David Hilton-Jones
John Newsom-Davis
David Beeson
and Nick Willcox. 11. Myasthenia Gravis Experimentally Induced with Muscle-specific Kinase: Kazuhiro Shigemoto
Sachiho Kubo
Chen Jie
Naohito Hato
Yasuhito Abe
Norifumi Ueda
Naoto Kpbayashi
Kenji Kameda
Katsumi Mominoki
Atsuo Miyazawa
Akihito Ishigami
Seiji Matsuda
and Naoki Maruyama. Part IV: Congenital Myasthenic Syndromes:. 12. Congenital Myasthenic Syndromes and the Formation of the Neuromuscular Junction: David Beeson
Richard Webster
Judith Cossins
Daniel Lashley
Hayley Spearman
Susan Maxwell
Clark Slater
John Newsom-Davis
Jacqueline Palace
and Angela Vincent. 13. Further Observations in Congenital Myasthenic Syndromes: Andrew G. Engel
Andrew G. Engel
Xin-Ming Shen
Duygu Selcen
and Steven M. Sine. Part V: Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins:. 14. Antiganglioside Antibodies and the Presynaptic Motor Nerve Terminal: Hugh John Willison and Jaap J. Plomp. 15. Neuronal Acetylcholine Receptor Autoimmunity: Steven Vernino. 16. Lambert-Eaton Myasthenic Syndrome: Tumor versus Non-tumor Forms: Maarten Titulaer and Jan JGM Verschuuren. Part VI: Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts:. 17. Pathogenic and Regulatory Mechanisms in Myasthenia Gravis: Rozen Le Panse
Géraldine Cizeron-Clairac
Mélinée Cuvelier
Frédérique Truffault
Jacky Bismuth
Patrice Nancy
Nicole Kerlero de Rosbo
and Sonia Berrih-Aknin. 18. Common Cellular and Diverse Genetic Basis of Thymoma-associated Myasthenia Gravis: Role of MHC class II and AIRE Genes
and Genetic Polymorphisms: Philipp Ströbel
Wen-Yu Chuang
Sergei Chuvpilo
Andreas Zettl
Tiemo Katzenberger
Hubert Kalbacher
Peter Rieckmann
Wilfred Nix
Berthold Schalke
Ralf Gold
Hans-Konrad Müller-Hermelink
Pärt Peterson
and Alexander Marx. 19. How Promiscuity Promotes Tolerance: The Case of Myasthenia Gravis: Bruno Kyewski and Richard Taubert. 20. Autoimmunizing Mechanisms in Thymoma and Thymus: Nicholas Willcox
Maria Isabel Leite
Yoshihisa Kadota
Margaret Jones
Anthony Meager
Peddasomayajula Subrahmanyam
Bhaskar Dasgupta
B Paul Morgan
and Angela Vincent. 21. Prevention of Acetylcholine Receptor Modulation in Myasthenia Gravis: Mario Losen
Pilar Martínez-Martínez
Marko Phernambucq
Janine Schuurman
Paul W.H.I Parren
and Marc De Baets. 22. Genetic Factors in Autoimmune Myasthenia Gravis: Matthieu Giraud
Claire Vandiedonck
and Henri-Jean Garchon. 23. CD4+ T Cells and Cytokines in the Pathogenesis of Acquired Myasthenia Gravis: Bianca Conti-Fine
Monica Milani
and Wei Wang. 24. Classical Complement Pathway in Experimental Autoimmune Myasthenia Gravis Pathogenesis: Premkumar Christadoss
Erdem Tüzün
Jing Li
Shamsher S. Saini
and Huan Yang. 25. Extraocular Muscle Susceptibility to Myasthenia Gravis: Unique Immunological Environment?: Jindrich Soltys
Bendi Gong
Henry J. Kaminski
Yuefang Zhou
and Linda L. Kusner. Part VII: Clinical Trials of Myasthenia Gravis:. 26. Treatment and Clinical Research in Myasthenia Gravis: How Far Have We Come?: Richard J. Barohn. 27. Rules of Evidence for Clinical Trials-The Science of Finding the Truth?: Gary Cutter and Inmaculada Aban. 28. Myasthenia Gravis in the Elderly: Is It Different?: Johan A. Aarli. 29. Immunosuppression of EAMG by Intravenous Immunoglobulin Is Mediated by a Disease-specific Anti-immunoglobulin Fraction: Sara Fuchs
Tali Feferman
Roberto Meidler
Raanan Margalit
Camille Sicsic
Talma Brenner
Orgad Laub
and Miriam C. Souroujon. 30. Lessons from Two Trials of Mycophenolate Mofetil in Myasthenia Gravis: Donald B. Sanders and Zaeem A. Siddiqi. 31. Tacrolimus for Myasthenia Gravis: A Clinical Study of 212 Patients: Jose M. Ponseti
Josep Gamez
Jamal Azem
Manuel López-Cano
Ramón Vilallonga
and Manuel Armengola. 32. Intravenous Immunoglobulin Treatment for Myasthenia Gravis: Effectiveness
Limitations and Novel Therapeutic Strategies: Lorne Zinman. 33. Treatment of Myasthenia Gravis Acute Exacerbations with Intravenous Immunoglobulin: Philippe Gajdos and Sylvie Chevret. Part VIII: Treatments on the Horizon for Myasthenia Gravis:. 34. Strategies for Immunoregulation: Novel Insights from Experimental Myasthenia Gravis: Matthew N. Meriggioli
JianRong Sheng
LiangCheng Li
and Bellur S. Prabhakar. 35. Antisense Treatment for Myasthenia Gravis: Experience with Monarsen: Jon D. Sussman
Zohar Argov
David McKee
Eli Hazum
Solli Brawer
and Hermona Soreq. 36. Antigen-specific Apheresis of Pathogenic Autoantibodies from Myasthenia Gravis Sera: Socrates J. Tzartos
Kalliopi Bitzopoulou
Ira Gavra
Grigoris Kordas
Leslie Jacobson
Kalliopi Kostelidou
George Lagoumintzis
Orestis Lazos
Kostantinos Poulas
Sotiris Sideris
Alexandros Sotiriadis
Nikos Trakas
and Paraskevi Zisimopoulou. 37. Etanercept Treatment in Myasthenia Gravis: Julie Rowin. 38. Rebooting the Immune System with High Dose Cyclophosphamide for Treatment of Refractory Myasthenia Gravis: Daniel B. Drachman
Robert N. Adams
Rong Hu
Richard J. Jones
and Robert A. Brodsky. Part IX: Panel Discussion: Thymectomy for Myasthenia Gravis:. 39. Thymectomy for Nonthymomatous Myasthenia Gravis-A Critical Analysis: Joshua R. Sonett and Alfred Jaretzki III. 40. Thoracoscopic Thymectomy with the Da-Vinci Robotic System for Myasthenia Gravis: Jens C. Rückert
Mahmoud Ismail
Marc Swierzy
Holger Sobel
Patrik Rogalla
Andreas Meisel
Klaus D. Wernecke
Ralph I. Rückert
Joachim M. Müller. 41. Extended Transcervical Thymectomy in the Treatment of Myasthenia Gravis: Sanjay G. Khicha
Larry R. Kaiser
and Joseph B. Shrager. 42. Status of the Thymectomy Trial for Nonthymomatous Myasthenia Gravis Patients Receiving Prednisone: John Newsom-Davis