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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Myeloma Protein is usually a monoclonal antibody or immunoglobulin fragment that is produced by malignant myeloma cells, or plasma cells. Other terms for this protein is M-protein, spike protein,or paraprotein. This proliferation of the myeloma protein has several deleterious effects on the body, including impaired immune function, abnormally high viscosity ("thickness") of the blood, and kidney damage.