I am pI eased to present to the readers the Proceedings of the Second International Congress on Myocardial and Cellular Bioenerge tics and Compartmentation which was held in Los Angeles during February 16-18, 1984. I would I ike to express my deep appreciation to all those who have encouraged us to hold the Second International Congress. This endeavor could not have been possible without the generous finan cial support of the following: The American Society for Magnesium Research, The University of Southern California Department of Con tinuing Medical Education, Alpha Therapeutics, ALSEB…mehr
I am pI eased to present to the readers the Proceedings of the Second International Congress on Myocardial and Cellular Bioenerge tics and Compartmentation which was held in Los Angeles during February 16-18, 1984. I would I ike to express my deep appreciation to all those who have encouraged us to hold the Second International Congress. This endeavor could not have been possible without the generous finan cial support of the following: The American Society for Magnesium Research, The University of Southern California Department of Con tinuing Medical Education, Alpha Therapeutics, ALSEB Scientific Products, The American Physiological Society, Ciba-Geigy Corpora tion, Victor Gura, M.D., Merck Sharp and Dohme, Phosphoenergetics, Stuart Pharmaceuticals, and the Upjohn Company. A note of special thanks goes to Samuel Bessman, M.D., who has been a source of constant support and encouragement for this Con gress and for my research endeavors. Nachman Brautbar vii CONTENTS I. HICROCOMPARTHENTATION AND ENERGY TRANSPORT: The Physiological Significance of the Creatine Phosphate Shuttle . . . . . . . .. . . ........ .
I. Microcompartmentation and Energy Transport.- The Physiological Significance of the Creatine Phosphate Shuttle.- Organization of the Mitochondrial Matrix.- The Time Course of ATP Cleavage by Contracting Amphibian and Mammalian Skeletal Muscles.- Isozymes of Creatine Kinase in Mammalian Myocardial Cell Culture.- Microcompartmentation at the Mitochondrial Surface: Its Function in Metabolic Regulation.- The Effect of Inorganic Phosphate on Mitochondrial Creatine Kinase.- Hormonal Regulation of Creatine Kinase BB.- Compartmentation of Adenine Nucleotides and Phosphocreatine Shuttle in Cardiac Cells: Some New Evidence.- Compartmentation of Hormone Action in Adult Mammalian Cardiomyocytes.- Function of Creatine Kinase Localization in Muscle Contraction.- Isotope Labeling Ratios: A Tool for the Exploration of Metabolic Compartments.- The Mitochondrial Creatine Phosphokinase is Associated with Inner Membrane Cardiolipin.- A Role for Mitochondria in Myocardial Adenosine Production.- II. Respiration Control - Cellular and Organ Level.- Aspects of Heart Respiratory Control by the Mitochondrial Isozyme of Creatine Kinase.- Control of Respiration in Intact Muscle.- Energy Compartmentation and Active Transport in Proximal Kidney Tubules.- The Oxygen Dependence of Cellular Energy Metabolism.- Regulation of Mitochondrial Respiration in Liver.- Quantitation of Fluxes in the Gluconeogenic, Glycolytic, and Pentose Phosphate Pathways in Isolated Rat Hepatocytes: Energetic Considerations.- Why is There a Delay in the Increased Oxygen Consumption During the Rest-Work Transition in Skeletal Muscles.- III. Myocardial Preservation, Ischemia: Cellular Mechanisms.- Compartmentation and Functional Mechanisms in Myocardial Failure and Myocardial Infarction.- Myocardial Protection ofHypertrophied Hearts by Administration of Cardioplegia According to Regional Myocardial Temperature.- Heart Myocytes as Models of the Cellular Response to Ischemia.- Biologic Basis for Limitation of Infarct Size.- Mitochondrial Transmembrane Proton Electrochemical Potential, Di- and Tricarboxylate Distribution and the Poise of the Malate-Aspartate Cycle in the Intact Myocardium.- Sarcomere Length-tension Relationship in Toad Atrioventricular Pacemaker: Length Dependent Activation.- Myocardial Acidosis and the Mitigation of Tissue ATP Depletion in Ischemic Cardiac Muscle: The Role of the Mitochondrial ATPase.- Vascular Metabolism and Energetics.- Myocardial Glutamate Dehydrogenase Activity.- Long Term Model for Evaluation of Myocardial Metabolic Recovery Following Global Ischemia.- The Effect of Reperfusion and Streptokinase on Ischemic Myocardium Serum Creatine Kinase Activity, MM Subtypes and Myocardial Blood Flow.- Post-contracture Reperfusion: Effect of Elevated Potassium and Verapamil.- Ultrastructure of the Human Myocardium after Intermittent Ischemia Compared to Cardioplegia.- IV. Pathophysiology of Energy Compartmentation.- Cellular Injury in Phosphate Depletion: Pathogenesis and Mechanisms in the Myocardium.- Diabetes Mellitus and Hypothyroidism Induce Changes in Myosin Isoenzyme Distribution in the Rat Heart - Do Alterations in Fuel Flux Mediate These Changes?.- Glycerol Kinase Deficiency: Compartmental Considerations Regarding Pathogenesis and Clinical Heterogeneity.- Phosphorylated Nucleotides and Glycolytic Intermediates in Diabetic and Non-diabetic Rat uterus in Late Pregnancy.- Effect of Calcium Antagonists on Vasopressin Induced Changes in Myocardial and Renal Pyridine Nucleotides in the Intact Rat.- The Effect of Creatine Analogue Substitution on thePost Tetanic Response of Fast Muscle.- V. Divalent Ions and Cellular Bioenergetics.- Calcium Compartmentation in Mammalian Myocardium.- Calcium Channel Blockers, Beta Blockers and the Maintenance of Calcium Homeostasis.- Sodium-Calcium Exchange: Calcium Regulation at the Sarcolemma.- The Calcium Pumping ATPase of Heart Plasma Membrane.- Calcium Compartmentation and Regulation in Myocytes.- Ca++-Dependent and Ca++-Independent Effects of Mg++ on Canine Right Atria.- Chronotropic and Inotropic Effects of [Mg++]o Not Dependent upon [Ca++]o.- Sodium Modulation of Resting Force, Contractile Properties, and Metabolism with Particular Emphasis on its Role in the Development of Calcium Overload States.- The Effect of Short Chain Fatty Acid Administration on Hepatic Glucose, Phosphate, Magnesium and Calcium Metabolism.- VI. 31-P NMR.- Lessons for Muscle Energetics from 31P NMR Spectroscopy.- Metabolic Depletion Preceding Cytolysis Induced by Antibody and Complement as Revealed by 31P-NMR Spectroscopy.
I. Microcompartmentation and Energy Transport.- The Physiological Significance of the Creatine Phosphate Shuttle.- Organization of the Mitochondrial Matrix.- The Time Course of ATP Cleavage by Contracting Amphibian and Mammalian Skeletal Muscles.- Isozymes of Creatine Kinase in Mammalian Myocardial Cell Culture.- Microcompartmentation at the Mitochondrial Surface: Its Function in Metabolic Regulation.- The Effect of Inorganic Phosphate on Mitochondrial Creatine Kinase.- Hormonal Regulation of Creatine Kinase BB.- Compartmentation of Adenine Nucleotides and Phosphocreatine Shuttle in Cardiac Cells: Some New Evidence.- Compartmentation of Hormone Action in Adult Mammalian Cardiomyocytes.- Function of Creatine Kinase Localization in Muscle Contraction.- Isotope Labeling Ratios: A Tool for the Exploration of Metabolic Compartments.- The Mitochondrial Creatine Phosphokinase is Associated with Inner Membrane Cardiolipin.- A Role for Mitochondria in Myocardial Adenosine Production.- II. Respiration Control - Cellular and Organ Level.- Aspects of Heart Respiratory Control by the Mitochondrial Isozyme of Creatine Kinase.- Control of Respiration in Intact Muscle.- Energy Compartmentation and Active Transport in Proximal Kidney Tubules.- The Oxygen Dependence of Cellular Energy Metabolism.- Regulation of Mitochondrial Respiration in Liver.- Quantitation of Fluxes in the Gluconeogenic, Glycolytic, and Pentose Phosphate Pathways in Isolated Rat Hepatocytes: Energetic Considerations.- Why is There a Delay in the Increased Oxygen Consumption During the Rest-Work Transition in Skeletal Muscles.- III. Myocardial Preservation, Ischemia: Cellular Mechanisms.- Compartmentation and Functional Mechanisms in Myocardial Failure and Myocardial Infarction.- Myocardial Protection ofHypertrophied Hearts by Administration of Cardioplegia According to Regional Myocardial Temperature.- Heart Myocytes as Models of the Cellular Response to Ischemia.- Biologic Basis for Limitation of Infarct Size.- Mitochondrial Transmembrane Proton Electrochemical Potential, Di- and Tricarboxylate Distribution and the Poise of the Malate-Aspartate Cycle in the Intact Myocardium.- Sarcomere Length-tension Relationship in Toad Atrioventricular Pacemaker: Length Dependent Activation.- Myocardial Acidosis and the Mitigation of Tissue ATP Depletion in Ischemic Cardiac Muscle: The Role of the Mitochondrial ATPase.- Vascular Metabolism and Energetics.- Myocardial Glutamate Dehydrogenase Activity.- Long Term Model for Evaluation of Myocardial Metabolic Recovery Following Global Ischemia.- The Effect of Reperfusion and Streptokinase on Ischemic Myocardium Serum Creatine Kinase Activity, MM Subtypes and Myocardial Blood Flow.- Post-contracture Reperfusion: Effect of Elevated Potassium and Verapamil.- Ultrastructure of the Human Myocardium after Intermittent Ischemia Compared to Cardioplegia.- IV. Pathophysiology of Energy Compartmentation.- Cellular Injury in Phosphate Depletion: Pathogenesis and Mechanisms in the Myocardium.- Diabetes Mellitus and Hypothyroidism Induce Changes in Myosin Isoenzyme Distribution in the Rat Heart - Do Alterations in Fuel Flux Mediate These Changes?.- Glycerol Kinase Deficiency: Compartmental Considerations Regarding Pathogenesis and Clinical Heterogeneity.- Phosphorylated Nucleotides and Glycolytic Intermediates in Diabetic and Non-diabetic Rat uterus in Late Pregnancy.- Effect of Calcium Antagonists on Vasopressin Induced Changes in Myocardial and Renal Pyridine Nucleotides in the Intact Rat.- The Effect of Creatine Analogue Substitution on thePost Tetanic Response of Fast Muscle.- V. Divalent Ions and Cellular Bioenergetics.- Calcium Compartmentation in Mammalian Myocardium.- Calcium Channel Blockers, Beta Blockers and the Maintenance of Calcium Homeostasis.- Sodium-Calcium Exchange: Calcium Regulation at the Sarcolemma.- The Calcium Pumping ATPase of Heart Plasma Membrane.- Calcium Compartmentation and Regulation in Myocytes.- Ca++-Dependent and Ca++-Independent Effects of Mg++ on Canine Right Atria.- Chronotropic and Inotropic Effects of [Mg++]o Not Dependent upon [Ca++]o.- Sodium Modulation of Resting Force, Contractile Properties, and Metabolism with Particular Emphasis on its Role in the Development of Calcium Overload States.- The Effect of Short Chain Fatty Acid Administration on Hepatic Glucose, Phosphate, Magnesium and Calcium Metabolism.- VI. 31-P NMR.- Lessons for Muscle Energetics from 31P NMR Spectroscopy.- Metabolic Depletion Preceding Cytolysis Induced by Antibody and Complement as Revealed by 31P-NMR Spectroscopy.
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