Myocardial stress adaptation: role of hyperlipidemia - Kocsis, Gabriella F.;Ferdinandy, Peter;Csont, Tamas
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We' ve shown for the first time that gene expression pattern is altered in the myocardium of cholesterol-fed mouse in response to ischemic preconditioning. This effect is apparent in the regulation of NO signaling, oxidant producing enzymes, and the mevalonate pathway. Our was the first demonstration in human apoB-100 transgenic mice, that hypercholesterolemia but not hypertriglyceridemia is responsible for the hyperlipidemia-induced, peroxynitrite-mediated cardiac dysfunction, and that increased cardiac NADPH oxidase activity is a major source of increased oxidative stress in…mehr

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Produktbeschreibung
We' ve shown for the first time that gene expression pattern is altered in the myocardium of cholesterol-fed mouse in response to ischemic preconditioning. This effect is apparent in the regulation of NO signaling, oxidant producing enzymes, and the mevalonate pathway. Our was the first demonstration in human apoB-100 transgenic mice, that hypercholesterolemia but not hypertriglyceridemia is responsible for the hyperlipidemia-induced, peroxynitrite-mediated cardiac dysfunction, and that increased cardiac NADPH oxidase activity is a major source of increased oxidative stress in hypercholesterolemia. We observed first, that acute lovastatin treatment abolished the infarct size-limiting effect of ischemic preconditioning and that chronic lovastatin treatment attenuated the protective effect of ischemic postconditioning. We've also proposed that acute and chronic lovastatin treatment might modulated the cardioprotective mechanisms through different cellular pathways.
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Autorenporträt
Kocsis, G. was born in 1977. She graduated in Chemistry (MSc, 2000) and in Theoretical Medicine (PhD, 2010). She started working in the field of experimental cardiology in 1998. During her PhD years her aim was to increase her knowledge on myocardial stress adaptation, focusing on further understanding the role of hyperlipidemia in this phenomenon.