COVID-19 is one of the deadliest Pandemic in the history. The virus was first identified in Wuhan, China in December 2019. WHO declared it to be a Pandemic on 11th March, 2020. As no specific treatment is available for this disease, it is important to know the various characteristics of the virus & how infection can be avoided. The virus is to be studied in detail for taking appropriate preventive measures. The book describes lessons learnt from Pandemics, COVID-19 management, prevention & control. Vaccine trial, Genome Sequencing & variants of COVID-19 are also included. Due to Pandemic, the things have changed for the people & they have been discussed as implications related to COVID-19 infection & disease. Sero-surveillance to study the immune status of the community has been incorporated. How to Contain COVID-19 infection in health care settings & the community along with use of face mask/ coverings have also been discussed.