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The book gives a concise and updated information about two important immunohistochemical markers N cadherin and Hyaluronan in squmous cell carcinoma in head and neck region and this may provide no hope in future for target therapy in this type of cancer. Also it includes practical work and study of these markers on paraffin embedded tissue and found out the correlations of expression of these tissue markers to clinicopathologic characters of these tumors and also correlated them to clinical outcomes of patients.