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This book examines the impact of politics on the implementation of the National Drug Policy by the National Agency for Food and Drug Administration and Control (NAFDAC) between the years 2001 and 2008. The implementation of the National Drug Policy is a collaborative effort between NAFDAC as the main implementer and other stakeholders, institutions and agencies which include the public bureaucracy, the private sector and political office-holders, among others. Through an appropriate combination of quantitative and qualitative research methods, the researcher found that NAFDAC was encumbered with problems in the implementation of the National Drug Policy during the period under review. The major problem with NAFDAC's implementation of the National Drug Policy bothered on how the various stakeholders played the political game of implementation, which exposed the capricious linkage between political economy and the implementation of public policies in Nigeria. Thus, the research findings link the rentier nature of the Nigerian state and the accumulative tendencies of her public office-holders with the ineffectiveness of many public policies and programmes in the country.