Jie Jack Li, E. J. Corey

Name Reactions of Functional Group Transformations

• Gebundenes Buch

Produktbeschreibung

Functional group transformations form the heart of organic synthesis, with one functional group present in the starting material transformed into a different functional group in the product. For purposes of this book, this includes oxidations, reductions, asymmetric transformations, and other functional group manipulations that are name reactions. Widespread applications of these reactions are used in the pharmaceutical, fine chemical, polymer, and ag/biotech industries.

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A survey of important transformations that are representative of the whole range of functional groups

This comprehensive reference delves into the details of name reactions that are important to researchers. It presents an up-to-date account of forty-seven major classes of functional group transformations and also serves to interconnect them. The book includes reviews from leading scientists in their specialty areas--all organized uniformly, making it easy to access information.

Topics are organized into the following sections:
_ Asymmetric synthesis
_ Reduction
_ Oxidation
_ Olefination
_ Amine synthesis
_ Carboxylic acid derivatives synthesis
_ Miscellaneous functional group manipulations

Each section includes a description of:
_ The functional group transformation
_ Mechanisms
_ Synthetic utilities and applications for the reaction
_ References to the primary literature
_ The historical perspective
_ Variations andimprovementon the reaction
_ Experimental details

With nineteen contributors from academia and industry, some of whom discovered the reactions they describe, Name Reactions for Functional Group Transformations is a state-of-the-art resource for organic and medicinal chemists conducting research in industries such as pharmaceuticals, fine chemicals, ag-biotech, and polymers, as well as for graduate students in organic chemistry. It is an ideal companion to the first volume of this series, Name Reactions in Heterocyclic Chemistry.

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Produktdetails

• Comprehensive Name Reactions
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 768
• Erscheinungstermin: 1. Juni 2007
• Englisch
• Abmessung: 260mm x 183mm x 45mm
• Gewicht: 1460g
• ISBN-13: 9780471748687
• ISBN-10: 0471748684
• Artikelnr.: 22579180

Autorenporträt

Jie Jack Li is a medicinal chemist at Pfizer Global Research and Development in Ann Arbor, Michigan. He is coauthor of Contemporary Drug Synthesis and editor of Name Reactions in Heterocyclic Chemistry (both from Wiley). E. J. Corey, Professor Emeritus at Harvard University, is scientific editorial advisor for this book. Dr. Corey won the Nobel Prize in Chemistry in 1990 for his development of the theory and methodology of organic synthesis, and was awarded the Priestley Medal in 2004.

Inhaltsangabe

Foreword vii
Preface viii
Contributing Authors ix
Chapter 1. Asymmetric Synthesis 1
Chapter 2. Reduction 85
Chapter 3. Oxidation 159
Chapter 4. Olefination 333
Chapter 5. Amine Synthesis 423
Chapter 6. Carboxylic Acid Derivatives Synthesis 457
Chapter 7. Miscellaneous Functional Group Manipulations 551
Appendixes 697
Appendix 1. Table of Contents for Volume 1: Name Reactions in Heterocyclic
Chemistry 697
Appendix 2. Table of Contents for Volume 3: Name Reactions for Chain
Extension 700
Appendix 3. Table of Contents for Volume 4: Name Reactions for Ring
Formation 703
Appendix 4. Table of Contents for Volume 5: Name Reactions in Heterocyclic
Chemistry-2 705
Subject Index 709

Rezensionen

"Unlike many previous books on name reactions, which present many reactions but treat them superficially, this book provides an excellent selection of useful name reactions, which have been given in depth, well-illustrated, instructional, and well-referenced accounts." ( Journal of Medicinal Chemistry , February 2008)
"Helps you explore how you think, communicate and react, allowing you to change your behaviours and become a more expert professional practitioner." ( Journal of Perioperative Practice , April 2008)

"Reading this book has been enjoyable experience. Again and again, one comes across surprising reaction possibilities of well-known reagents, or some lesser known variants of common transformations." ( Angewandte Chemie )

"This book provides an excellent selection of useful name reactions, which have been given in depth, well-illustrated, instructional, and well-referenced accounts." ( Journal of Medicinal Chemistry , January 11, 2008)