Biofilms are the main reason behind the majority of dental diseases, with dental caries being the most prevalent. The incidence of dental caries is growing worldwide in adults and children. About 90% of adults reported having dental caries, 26% of which were untreated Moreover, medical and dental challenges are more prevalent in the elderly, which can worsen damage created by dental caries. For example, in an elderly population with systemic diseases, the consumption of certain medicines can cause hyposalivation, that can higher their chances of having cariogenic microorganism that lead to dental caries.