This manuscript tries to touch the different materials characterized to be used for preparation of nanomedicines with a brief review of exemplary applications in pipeline and already marketed under FDA approval.It also touches the techniques to formulate nanomaterials in nanomedicines ,their characterization and the challenges behind production and marketing for medicines compared to ordinary products manufacturing procedures.Hopefully, it will give updated information on materials used in nanomedicines and their application ,achievements and available challenges ahead.